机构：[1] Guangzhou Univ Chinese Med, Inst Clin Med 2, Guangzhou, Guangdong, Peoples R China[2] Guangdong Prov Acad Chinese Med Sci, Lab Chinese Mat Med Preparat, Guangzhou, Guangdong, Peoples R China[3] Guangzhou Univ Chinese Med, Postdoctoral Res Stn, Guangzhou, Guangdong, Peoples R China[4] Peking Univ, Coll Chem & Mol Engn, State Key Lab Rare Earth Mat Chem & Applicat, BNLMS, Beijing, Peoples R China[5] Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Guangzhou, Guangdong, Peoples R China
Introduction: Psoriasis is a refractory skin disorder, and usually requires a lifetime control. Traditional Chinese medicine (TCM) is effective and safe for this disease. However, the cellular and molecular mechanisms of TCM remedies for psoriasis are still not fully understood. TCM contains numerous natural products. Natural products have historically been invaluable as a resource of therapeutic agents. Yet, there is no integrated information about active compounds of TCM for psoriasis. Method: We use systems pharmacology methods to develop the Psoriasis Database of Traditional Chinese Medicine (PDTCM). The database covered a number of psoriasis-related information (formulas, TCM, compounds, target proteins, diseases and biomarkers). With these data information, an online platform was constructed Results: PDTCM comprises 38 empirical therapeutic formulas, 34373 compounds from 1424 medicinal plants, 44 psoriasis-related proteins and 76 biomarkers from 111 related diseases. On this platform, users can screen active compounds for a psoriasis-related target and explore molecular mechanisms of TCM. Accordingly, users can also download the retrieved structures and data information with a defined value set. In addition, it helps to get a better understanding of Chinese prescriptions in disease treatment. Conclusion: With the systems pharmacology-based data, PDTCM would become a valuable resource for TCM in psoriasis-related research.
基金：
Ministry of Science and Technology, ChinaMinistry of Science and Technology, China [2013BAI02B03]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [S2013030011515]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81302736]; Guangdong Science and Technology Department [2014A020221040, 2016A020226010, 2017A020213011]; Financial Industry Technology Research Development Program of Guangdong Province of China [2011(285)05]; special research on Chinese Medical Science and Technology of Guangdong Provincial Hospital of Chinese Medicine [YK2013B1N02, YN2014ZH07]; Guangzhou University of Chinese Medicine [A1-AFD018161Z04]
第一作者机构：[1] Guangzhou Univ Chinese Med, Inst Clin Med 2, Guangzhou, Guangdong, Peoples R China[2] Guangdong Prov Acad Chinese Med Sci, Lab Chinese Mat Med Preparat, Guangzhou, Guangdong, Peoples R China[3] Guangzhou Univ Chinese Med, Postdoctoral Res Stn, Guangzhou, Guangdong, Peoples R China
通讯作者：
通讯机构：[*1]Guangdong Prov Acad Chinese Med Sci, Lab Chinese Mat Med Preparat, Guangzhou, Guangdong, Peoples R China[2] Guangdong Prov Acad Chinese Med Sci, Lab Chinese Mat Med Preparat, Guangzhou, Guangdong, Peoples R China
推荐引用方式(GB/T 7714)：
Wang Dongmei,Gu Jiangyong,Zhu Wei,等.PDTCM: a systems pharmacology platform of traditional Chinese medicine for psoriasis[J].ANNALS OF MEDICINE.2017,49(8):652-660.
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