机构：[1] Guangzhou Univ Chinese Med, Clin Med Coll 2, Guangzhou 510120, Guangdong, Peoples R China[2] Southwest Med Univ, Chinese Med Hosp, Luzhou 646000, Peoples R China[3] Guangzhou Univ Chinese Med, Clin Sch Acupuncture & Rehabil, Guangzhou 510405, Guangdong, Peoples R China
Somatic stimulation therapy, such as electroacupuncture (EA), has been widely applied in the clinic to treat dysphagia. However, its underlying mechanism has remained unknown. In the present study, the effect of EA at acupoints Fengfu (DU16) and Lianquan (RN23) on swallowing activities and the involvement of 5-HT1A in the nucleus of the solitary tract (NTS) were examined in anesthetized rats. EA at DU16 and RN23 significantly evoked myoelectric activity of the mylohyoid muscle, which was attenuated by injection of 10 nmol 5-HT1A antagonist (WAY-100635) into the NTS. Meanwhile, 5-HT1A expression in the NTS increased following EA. The results suggested that EA at DU16 and RN23 promotes swallowing activity, and 5-HT1A in the NTS may play an important role in the excitatory effects.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81273675, 81673888]; Special Research Program for TCM Science and Technology of Guangdong Province TCM hospital [YK2013BIN08]
第一作者机构：[1] Guangzhou Univ Chinese Med, Clin Med Coll 2, Guangzhou 510120, Guangdong, Peoples R China[2] Southwest Med Univ, Chinese Med Hosp, Luzhou 646000, Peoples R China
通讯作者：
通讯机构：[1] Guangzhou Univ Chinese Med, Clin Med Coll 2, Guangzhou 510120, Guangdong, Peoples R China[*1]Guangzhou Univ Chinese Med, Clin Med Coll 2, Guangzhou 510120, Guangdong, Peoples R China[*2]Guangzhou Univ Chinese Med, Clin Sch Acupuncture & Rehabil, Guangzhou 510405, Guangdong, Peoples R China[3] Guangzhou Univ Chinese Med, Clin Sch Acupuncture & Rehabil, Guangzhou 510405, Guangdong, Peoples R China
推荐引用方式(GB/T 7714)：
You Hui,Hu Shaowen,Ye Qiu-ping,等.Role of 5-HT1A in the nucleus of the solitary tract in the regulation of swallowing activities evoked by electroacupuncture in anesthetized rats[J].NEUROSCIENCE LETTERS.2018,687:308-312.
