机构：[1] Guangzhou Univ Chinese Med, Clin Med Coll 2, Guangzhou 510006, Guangdong, Peoples R China[2] Guangzhou Univ Chinese Med, Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Guangzhou 510006, Guangdong, Peoples R China[3] Guangzhou Univ Chinese Med, Guangdong Prov Key Lab New Drug Dev & Res Chinese, Guangzhou 510006, Guangdong, Peoples R China[4] Guangzhou Univ Chinese Med, Math Engn Acad Chinese Med, Guangzhou 510006, Guangdong, Peoples R China[5] Guangdong Prov Acad Chinese Med Sci, Guangzhou 510006, Guangdong, Peoples R China[6] ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China
Triptriolide (T11) is a natural diterpene diepoxide that derived from Chinese traditional herb medicine (TCHM) Tripterygium wilfordii Hook.F (TWHF). From a structural point of view, T11 is very similar to triptolide (T9), one of the most effectively compounds in TWHF that have already been systematically investigated in the past decades. However, the basic functions and medicinal properties of T11 have not yet been well investigated mainly due to its low abundance in its plant organ. The present study aimed to investigate the protective effects of T11 on puromycin aminonucleoside (PAN) induced apoptotic mouse podocytes and the underlying mechanism. The results showed that T11 had no significant toxicity in podocytes in high dosage, and showed prominent protective effects on PAN induced podocytes injury. Further studies indicated that T11 might exert its protective effects by inhibiting of apoptosis and restoring of survival in PAN induced podocytes.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81202398, 81774216, 81703379]; Specific Research Project of State Administration of TCM of China [JDZX2015207]; Guangdong Provincial Science and Technology Project [2014A030313400, 2014A020221035, 2015A020211025, 2015B020211013, 2017B030314166]; Guangzhou Science and Technology Project [201607010338, 201604016065]; Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine [YN2014ZHR209, YN2015MS03]; Key Project of High-level University Construction of Guangzhou University of Chinese Medicine [A1-AFD018171Z11097, A1-AFD018181 A34]
语种：
中文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|3 区医学：研究与实验3 区药学
最新[2025]版：
大类|2 区医学
小类|2 区医学：研究与实验2 区药学
JCR分区：
出版当年[2017]版：
Q2PHARMACOLOGY & PHARMACYQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[1] Guangzhou Univ Chinese Med, Clin Med Coll 2, Guangzhou 510006, Guangdong, Peoples R China[2] Guangzhou Univ Chinese Med, Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Guangzhou 510006, Guangdong, Peoples R China
通讯作者：
通讯机构：[*1]Guangdong Prov Acad Chinese Med Sci, Guangzhou 510006, Guangdong, Peoples R China[*2]ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China[5] Guangdong Prov Acad Chinese Med Sci, Guangzhou 510006, Guangdong, Peoples R China[6] ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China
推荐引用方式(GB/T 7714)：
Yang Yi-qi,Liang Jian,Han Xiao-dong,等.Dual-function of triptriolide in podocytes injury: inhibiting of apoptosis and restoring of survival[J].BIOMEDICINE & PHARMACOTHERAPY.2019,109:1932-1939.
