研究单位：[1]Guangdong Provincial Hospital of Traditional Chinese Medicine[2]China PLA General Hospital Beijing,Beijing,China,100000[3]China-Japan Friendship Hospital Beijing,Beijing,China,100000[4]Dongzhimen Hospital of Beijing University of Chinese Medicine Beijing,Beijing,China,100000[5]First Hospital of Peking University Beijing,Beijing,China,100000[6]Guang'anmen Hospital China Academy of traditional Chinese Medicine Beijing,Beijing,China,100000[7]Xiyuan Hospital,Academy of traditional Chinese Medicine Beijing,Beijing,China,100000[8]Third Military Medical University Xinqiao Hospital Chongqing,Chongqing,China,400037[9]General hospital of Guangzhou Military command of PLA Guangzhou,Guangdong,China,510000[10]Guangzhou No.1 People's Hospital Guangzhou,Guangdong,China,510000[11]Huadu District People's Hospital of Guangzhou Guangzhou,Guangdong,China,510000[12]TCM Integrated Hospital of Southern Medical University Guangzhou,Guangdong,China,510000[13]Guangdong Provincial Hospital of Chinese Medicine Guangzhou,Guangdong,China,510120[14]Liuzhou Hospital of traditional Chinese Medicine Liuzhou,Guangxi,China,545000[15]First Affiliated Hospital of Guangxi University Of Chinese Medicine Nanning,Guangxi,China,530000[16]First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine Guiyang,Guizhou,China,550000[17]First Affiliated Hospital of Heilongjiang University Of Chinese Medicine Ha'erbin,Heilongjiang,China,150000[18]Heilongjiang Academy of Traditional Chinese Medicine Ha'erbin,Heilongjiang,China,150000[19]Hubei Provincial Hospital of Chinese Medicine Wuhan,Hubei,China,430000[20]Jiangsu Provincial Hospital of Chinese Medicine Nanjing,Jiangsu,China,210000[21]Shaanxi Provincial Hospital of Chinese Medicine Xi'an,Shaanxi,China,710000[22]Xijing Hospital of The Fourth Military Medical University Xi'an,Shaanxi,China,710000[23]Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai,Shanghai,China,200000[24]The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University Shanghai,Shanghai,China,200000[25]First hospital of Shanxi Medical University Taiyuan,Shanxi,China,030000[26]Affiliated Hospital of Chengdu University of Traditional Chinese Medicine Chengdu,Sichuan,China,610000[27]First Affiliated Hospital of Tianjin University Of Chinese Medicine Tianjin,Tianjin,China,300000[28]Hangzhou Hospital of Chinese Medicine Hangzhou,Zhejiang,China,310000[29]Tong De Hospital,Zhejiang Province Hangzhou,Zhejiang,China,310000
研究目的：
Stage 5 chronic kidney disease (CKD), also end stage renal disease(ESRD), usually presents overt clinical symptoms and is a critical stage when patients are encountered with dialysis. The optimal time to initiating dialysis in patients with stage 5 CKD is addressed as the most important dialysis-related question. As indicated by the recently published European Renal Best Practice (ERBP) guideline, early initiation seemed to produce no benefit but greater expenditure and sometimes more harm.Renal replacement therapies (RRT) including dialysis are the most common procedures for patients with end-stage renal disease (ESRD), but conservative management should be an option in patients who still experience the stable period without clinical indications of dialysis.Chinese Medicine (CM) is recognized as an alternative therapy on alleviating uremic symptoms, deferring dialysis initiation, and improving quality of life. Although the effects of CM on kidney disease have been demonstrated in animal experiments, evidence from large clinical trial is insufficient. So we raise the hypothesis that CM therapies including Chinese herbal formula, Chinese patent medicine via oral pattern and/or Colonic administration, will defer the initiation of dialysis in adults with stage 5 CKD.
