Usefulness of New Shear Wave Elastography Technique for Noninvasive Assessment of Liver Fibrosis in Patients with Chronic Hepatitis B: A Prospective Multicenter Study.
机构：[1]Department of Ultrasound, Guangdong Key Laboratoryof Liver Disease Research, Third Affiliated Hospital ofSun Yat-Sen University, Guangzhou, China中山大学附属第三医院[2]Ultrasound Department of Fifth Medical Center of ChinesePLA General Hospital, Beijing, China[3]Department of Ultrasound, Xiamen Hospital of TraditionalChinese Medicine, Xiamen, China[4]Department of Ultrasound, Nanjing University MedicalSchool Affiliated Nanjing Drum Tower Hospital, Nanjing,China[5]Department of Ultrasound, National Clinical ResearchCenter for Infectious Disease, Department of Ultrasound,Shenzhen Third People’s Hospital, Second HospitalAffiliated to Southern University of Science andTechnology, Shenzhen, China深圳市康宁医院深圳医学信息中心[6]Department of ultrasound, Ruijin Hospital, School ofMedicine, Shanghai Jiaotong University, Shanghai, China[7]Department of Ultrasound, Guangzhou Eighth People'sHospital, Guangzhou Medical University, Guangzhou,China[8]Department of Ultrasound, Mianyang Center Hospital,Mianyang, China[9]Department of abdominal ultrasound, The First AffiliatedHospital of Xinjiang Medical University, Urumqi, China[10]Department of Ultrasound, First Affiliated Hospital,College of medicine, Zhejiang University, Hangzhou, China浙江大学医学院附属第一医院[11]Department of Ultrasound, Beijing Ditan Hospital, CapitalMedical University, Beijing, China[12]Department of Ultrasound, Ningbo Yinzhou No 2 Hospital,Ningbo, China[13]Department of Ultrasound, The First Hospital of LanzhouUniversity, Lanzhou, China[14]Ultrasound Imaging Department, Shenzhen TraditionalChinese Medicine Hospital, Shenzhen, China深圳市康宁医院深圳医学信息中心[15]Department of Ultrasound, Fuyang People's Hospital,Fuyang, China[16]Department of Ultrasound, Harbin Medical UniversityCancer Hospital, Harbin, China[17]Department of Ultrasound, Southwest Hospital, ArmyMedical University (Third Military Medical University),Chongqing, China[18]Department of Medical Ultrasonography, ShanghaiGeneral Hospital, Shanghai Jiaotong University School ofMedicine, Shanghai, China[19]Department of Ultrasound, Zhengzhou University FirstAffiliated Hospital, Zhengzhou, China[20]Department of Ultrasound, Xi'an Jiaotong UniversitySecond Affiliated Hospital, Xi'an, China[21]Ultrasonography, Shijiazhuang Fifth Hospital,Shijiazhuang, China[22]Ultrasound Department, Third Medical Center of PLAGeneral Hospital, Beijing, China[23]Department of Ultrasound, The Third Central Hospital ofTianjin, China[24]Department of Ultrasound, The Central Hospital ofWuhan,Tongji Medical College, Huazhong University of Scienceand Technology, Wuhan, China[25]Department of Ultrasound, Yichang Central People'sHospital, The First College of Clinical Medical Science,China Three Gorges University, Yichang, China[26]Department of Medical Ultrasound, Third Hospital ofLonggang, Shenzhen, China深圳市康宁医院深圳医学信息中心
To explore the usefulness of liver stiffness measurements (LSMs) by sound touch elastography (STE) and sound touch quantification (STQ) in chronic hepatitis B (CHB) patients for staging fibrosis. This prospective multicenter study recruited normal volunteers and CHB patients between May 2018 and October 2019. The volunteers underwent LSM by STE and supersonic shear imaging (SSI) or by STQ and acoustic radiation force impulse imaging (ARFI). CHB patients underwent liver biopsy and LSM by both STE/STQ. The areas under the receiver operating characteristic curves (AUCs) for staging fibrosis were calculated. Overall, 97 volunteers and 524 CHB patients were finally eligible for the study. The successful STE and STQ measurement rates were both 100 % in volunteers and 99.4 % in CHB patients. The intraclass correlation coefficients (ICCs) for the intra-observer stability of STE and STQ (0.94; 0.90) were similar to those of SSI and ARFI (0.95; 0.87), respectively. STE and STQ showed better accuracy than the aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 index (FIB-4) (AUC: 0.87 vs 0.86 vs 0.73 vs 0.77) in staging cirrhosis. However, both STE and STQ were not superior to APRI and FIB-4 in staging significant fibrosis (AUC: 0.76 vs 0.73 vs 0.70 vs 0.71, all P-values > 0.05). STE and STQ are convenient techniques with a reliable LSM value. They have a similar diagnostic performance and are superior to serum biomarkers in staging cirrhosis in CHB patients.Thieme. All rights reserved.
基金：
National Natural Science Foundation of China (No. 81827802)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|2 区医学
小类|2 区声学2 区核医学
最新[2025]版：
大类|2 区医学
小类|2 区声学3 区核医学
第一作者：
第一作者机构：[1]Department of Ultrasound, Guangdong Key Laboratoryof Liver Disease Research, Third Affiliated Hospital ofSun Yat-Sen University, Guangzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Ultrasound, Guangdong Key Laboratoryof Liver Disease Research, Third Affiliated Hospital ofSun Yat-Sen University, Guangzhou, China[2]Ultrasound Department of Fifth Medical Center of ChinesePLA General Hospital, Beijing, China[*1]Ultrasound Department of Fifth Medical Center of Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China[*2]Ultrasound Department, Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, 510630 Guangzhou, China
推荐引用方式(GB/T 7714)：
JinfenWang,Manli Wu,Runze Linghu,et al.Usefulness of New Shear Wave Elastography Technique for Noninvasive Assessment of Liver Fibrosis in Patients with Chronic Hepatitis B: A Prospective Multicenter Study.[J].Ultraschall In Der Medizin (Stuttgart, Germany : 1980).2021,doi:10.1055/a-1376-6734.
APA：
JinfenWang,Manli Wu,Runze Linghu,Jiandong Chang,MinWu...&Rong-Qin Zheng.(2021).Usefulness of New Shear Wave Elastography Technique for Noninvasive Assessment of Liver Fibrosis in Patients with Chronic Hepatitis B: A Prospective Multicenter Study..Ultraschall In Der Medizin (Stuttgart, Germany : 1980),,
MLA：
JinfenWang,et al."Usefulness of New Shear Wave Elastography Technique for Noninvasive Assessment of Liver Fibrosis in Patients with Chronic Hepatitis B: A Prospective Multicenter Study.".Ultraschall In Der Medizin (Stuttgart, Germany : 1980) .(2021)
