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Melatonin Synergizes With Methylprednisolone to Ameliorate Acute Spinal Cord Injury.

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机构： [1]Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. [2]Emergency Department, SongBei Hospital of the Fourth Hospital Affiliated with Harbin Medical University, Harbin, China. [3]Postdoctoral Workstation, Harbin Children's Hospital, Harbin, China. [4]Department of Orthopedics, Bejing Hospital of Traditional Chinese Medicine, Beijing, China. [5]Department of Spine Surgery, Orthopedics Center of Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China. [6]Department of Orthopedic Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China. [7]Department of Orthopedic Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

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关键词： melatonin methylprednisolone spinal cord injury factorial design PI3K-AKT1 pathway

摘要：

Methylprednisolone (MP) is the drug of choice for treating spinal cord injury (SCI), but the aggressive dosage regimen used often results in adverse side effects. Therefore, MP should be combined with other drugs to lower the required dose. Melatonin is effective in alleviating nerve damage and inhibiting axonal degeneration. The combination of melatonin and half-dose methylprednisolone (HMP) for spinal cord injury treatment has never been reported. In this study, we established a rat model of T9 spinal cord injury by the Allen's method and assessed the synergistic therapeutic effects of melatonin and HMP by factorial design. Our results demonstrated that melatonin could synergize with HMP to ameliorate acute SCI through PI3K-AKT1 pathway. Combining melatonin with HMP significantly reduced the standard-dose of methylprednisolone and limited its adverse reactions, representing a promising option for treating acute SCI.Copyright © 2022 Bi, Sun, Feng, Shen, Chen, Tan, Li and Lin.

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出版当年[2020]版：

大类 | 2 区医学

小类 | 2 区药学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区药学

第一作者：

第一作者机构： [1]Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. [2]Emergency Department, SongBei Hospital of the Fourth Hospital Affiliated with Harbin Medical University, Harbin, China. [3]Postdoctoral Workstation, Harbin Children's Hospital, Harbin, China.

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