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Radioactive Gold Nanoparticle in Two Forms (19879Au GNPs and 99mTc-GNPs) for Lung Cancer Antiproliferative Induction and Intralesional Imaging: A Proof of Concept.

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机构： [1]Medical Imaging Department, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. [2]Department of Interventional Radiology, Wuhan Third Hospital, Wuhan, Hubei, 430074, China. [3]Medical Imaging Department, Taixing People's Hospital, Taixing, Jiangsu, 225400, China. [4]Radiology Department of Minda Hospital of Hubei Minzu University, Enshi, Hubei, 445000, China. [5]Radiology Department, Chongqing Jiulongpo Hospital of Traditional Chinese Medicine, Chongqing, 400080, China. [6]Department of Radiotherapy，Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Shaanxi, Xianyang, 712000, China. [7]Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro, Brazil. [8]Zona Oeste State University, Laboratory of Nanoradiopharmacy, Rio de Janeiro, Brazil [9]Department of Medical Ultrasonic, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510630, China

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关键词： Radioactive gold lung cancer nanoparticles theranostic imaging cancer therapy

摘要：

Lung cancer is among the most common cancers worldwide, responsible for 13% of all new cancer cases. Also, it is the leading cause of cancer death among both men and women. In this scenario, an effective and efficient treatment is required.Production of two gold nanoparticles: 198Au and 99mTc-Au. The first one has been produced from irradiation of the 197Au in order to produce a beta-emitter gold nanoparticle for cancer therapy. The second one has been produced from the radiolabeling of gold nanoparticles with technetium 99 metastable in order to produce imaging nanoagent.The 198Au nanoparticles were produced by irradiation and identified by hyper-purity germanium (HPGe). They were then evaluated in vitro in order to confirm the behavior on cell proliferation of lung cancer cell lines by the MTT methodology using A549 cells. The 99mTc-Au nanoparticles were produced by directradiolabeling with 99mTc and evaluated in vivo as intralesional nanoagent.The results showed that in both cases, all the nanoparticles have performed their duties with excellence. The 198Au nanoparticles were capable to kill lung cancer cells, while 99mTc-Au was capable to image the tumor after intralesional injection. In addition, 99mTc-Au nanoparticles were useful for biodistribution assay imaging, showing the main organs responsible for the nanoparticle uptake in healthy animals.Both gold nanoparticles showed to be a highly efficient nanoagent for both: therapy and diagnosing of lung cancer.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

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出版当年[2019]版：

大类 | 3 区医学

小类 | 3 区药物化学 4 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区药物化学 4 区肿瘤学

第一作者：

第一作者机构： [1]Medical Imaging Department, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.

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通讯作者：

通讯机构： [9]Department of Medical Ultrasonic, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510630, China [*1]Department of Medical Ultrasonic, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510630, China

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Radioactive Gold Nanoparticle in Two Forms (<sup>198</sup><sub>79</sub>Au GNPs and <sup>99m</sup>Tc-GNPs) for Lung Cancer Antiproliferative Induction and Intralesional Imaging: A Proof of Concept.

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