Gut microbiota is believed to play a crucial role in obesity. However, the consistent findings among published studies regarding microbiomeeobesity interaction are relatively rare, and one of the underlying causes could be the limited sample size of cohort studies. In order to identify gut microbiota changes between normal-weight individuals and obese individuals, fecal samples along with phenotype information from 2262 Chinese individuals were collected and analyzed. Compared with normal-weight individuals, the obese individuals exhibit lower diversity of species and higher diversity of metabolic pathways. In addition, various machine learning models were employed to quantify the relationship between obesity status and Body mass index (BMI) values, of which support vector machine model achieves best performance with 0.716 classification accuracy and 0.485 R-2 score. In addition to two well-established obesity-associated species, three species that have potential to be obesity-related biomarkers, including Bacteroides caccae, Odoribacter splanchnicus and Roseburia hominis were identified. Further analyses of functional pathways also reveal some enriched pathways in obese individuals. Collectively, our data demonstrates tight relationship between obesity and gut microbiota in a large-scale Chinese population. These findings may provide potential targets for the prevention and treatment of obesity. (c) 2021 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
基金：
National Natural Science Foundation of China [31600641, 81773687, 81703606, 81573501, 81473181]; Fundamental Research Funds for the Central Universities [DUT18RC(4)057]; National Key Research and Development Program of China [2017YFC1700200, 2017YFC1702000]; National S&T Major Projects of China [2017ZX09101004]
第一作者机构：[1]Dalian Univ Technol, Sch Life & Pharmaceut Sci, Panjin 124221, Peoples R China[2]KMHD, Dept Sci Res, Shenzhen 518126, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Dalian Univ Technol, Sch Life & Pharmaceut Sci, Panjin 124221, Peoples R China[*1]Dagong Rd 2, Panjin 124221, Peoples R China
推荐引用方式(GB/T 7714)：
Liu Wanjun,Fang Xiaojie,Zhou Yong,et al.Machine learning-based investigation of the relationship between gut microbiome and obesity status[J].MICROBES AND INFECTION.2022,24(2):104892.doi:10.1016/j.micinf.2021.104892.
APA：
Liu, Wanjun,Fang, Xiaojie,Zhou, Yong,Dou, Lihong&Dou, Tongyi.(2022).Machine learning-based investigation of the relationship between gut microbiome and obesity status.MICROBES AND INFECTION,24,(2)
MLA：
Liu, Wanjun,et al."Machine learning-based investigation of the relationship between gut microbiome and obesity status".MICROBES AND INFECTION 24..2(2022):104892
