机构：[1]Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University, Shanghai, China[2]Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China[3]Department of Pediatrics, Fuzhou Children’s Hospital of Fujian Medical University, Fuzhou, Fujian, China[4]Department of Neuroendocrinology Pediatrics, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China[5]Shenzhen Children’s Hospital, Shenzhen, Guangdong, China[6]Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai, China[7]Department of Endodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University Shanghai, China[8]Department of Periodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China
Background and Aim The relationship between the oral microbiota and type 1 diabetes (T1D) remains unclear. We aimed to evaluate the variations in the oral microbiome in T1D and identify potentially associated bacterial factors. Methods We performed high-throughput sequencing of the V3-V4 area of the 16S rRNA gene to profile the oral bacterial composition of 47 healthy children (CON group), 46 children with new-onset T1D in the acute phase (NT1D group), and 10 children with T1D in the chronic phase receiving insulin treatment (CT1D group). Multivariate statistical analysis of sequencing data was performed. Results Compared to the CON group, the NT1D group was characterized by decreased diversity and increased abundance of genera harboring opportunistic pathogens, while this trend was partially reversed in the CT1D group. Differential genera between groups could distinguish the NT1D group from the CON group (AUC = 0.933) and CT1D group (AUC = 0.846), respectively. Moreover, T1D-enriched genera were closely correlated with HbA1c, FBG and WBCs levels. Conclusion Our results showed that the acute phase of T1D was characterized by oral microbiota dysbiosis, which could be partially ameliorated via glycemic control. The possible role of oral microbiota dysbiosis on oral health and systemic metabolic status in T1D warrants further mechanistic investigation.
基金：
Clinical special project of integrated traditional Chinese and Western medicine in 2019; Shanghai Municipal Administrator of Traditional Chinese Medicine; National Natural Science Foundation of China [82004149]; Shanghai Collaborative Innovation Center for Chronic Disease Prevention and Health Services (2021 Science and Technology) [02-37]; Local Colleges Faculty Constitution of Shanghai MSTC [22010504300]; National Key Research and Development Program of China [2016YFC1305302]
第一作者机构：[1]Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University, Shanghai, China
通讯作者：
通讯机构：[1]Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University, Shanghai, China[6]Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai, China[*1]Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University, Shanghai, China[*2]Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai, Jiangsu, China
推荐引用方式(GB/T 7714)：
Yuan Xiaoxiao,Wu Jin,Chen Ruimin,et al.Characterization of the oral microbiome of children with type 1 diabetes in the acute and chronic phases[J].JOURNAL OF ORAL MICROBIOLOGY.2022,14(1):doi:10.1080/20002297.2022.2094048.
APA：
Yuan, Xiaoxiao,Wu, Jin,Chen, Ruimin,Chen, Zhihong,Su, Zhe...&Wang, Ruirui.(2022).Characterization of the oral microbiome of children with type 1 diabetes in the acute and chronic phases.JOURNAL OF ORAL MICROBIOLOGY,14,(1)
MLA：
Yuan, Xiaoxiao,et al."Characterization of the oral microbiome of children with type 1 diabetes in the acute and chronic phases".JOURNAL OF ORAL MICROBIOLOGY 14..1(2022)
