机构：[1]Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China[2]Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China[3]School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China[4]Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China[5]Research Center for Plants and Human Health, Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, National Agricultural Science & Technology Center, Chengdu 610213, China
Cancer has been a serious public health problem. Berberine is a famous natural compound from medicinal herbs and shows many bioactivities, such as antioxidant, anti-inflammatory, antidiabetic, anti-obesity, and antimicrobial activities. In addition, berberine shows anticancer effects on a variety of cancers, such as breast, lung, gastric, liver, colorectal, ovarian, cervical, and prostate cancers. The underlying mechanisms of action include inhibiting cancer cell proliferation, suppressing metastasis, inducing apoptosis, activating autophagy, regulating gut microbiota, and improving the effects of anticancer drugs. This paper summarizes effectiveness and mechanisms of berberine on different cancers and highlights the mechanisms of action. In addition, the nanotechnologies to improve bioavailability of berberine are included. Moreover, the side effects of berberine are also discussed. This paper is helpful for the prevention and treatment of cancers using berberine.
基金：
This research was funded by Local Financial Funds of National Agricultural Science and
Technology Center, Chengdu (No. NASC2021KR01), and the Key Project of Guangdong Provincial
Science and Technology Program (No. 2014B020205002).
第一作者机构：[1]Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
通讯作者：
推荐引用方式(GB/T 7714)：
Xiong Ruo-Gu,Huang Si-Yu,Wu Si-Xia,et al.Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review[J].MOLECULES.2022,27(14):doi:10.3390/molecules27144523.
APA：
Xiong Ruo-Gu,Huang Si-Yu,Wu Si-Xia,Zhou Dan-Dan,Yang Zhi-Jun...&Li Hua-Bin.(2022).Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review.MOLECULES,27,(14)
MLA：
Xiong Ruo-Gu,et al."Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review".MOLECULES 27..14(2022)
