机构：[1]Cancer Center, Faculty of Health Science, University of Macau, Macau (SAR), China. MOE Frontiers Science Center for Precision Oncology, University of Macau, Macau (SAR), China[2]Dr. Neher’s Biophysics Laboratory for Innovative Drug Discovery and State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China.[3]School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China[4]College of Life Science, Northwest Normal University, Lanzhou 730000, China[5]Department of Respiratory and Critical Care Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000[6]Shenzhen Key Laboratory of Drug Addiction, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences.Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China深圳市康宁医院深圳医学信息中心
Microbial neurotransmitters, as potential targets for cancer therapy, are expected to provide a new perspective on the interaction between the gut microbiome and cancer immunotherapy. Recent Advance: Mounting data reveal that most neurotransmitters can be derived from gut microbiota. Furthermore, modulation of neurotransmitter signaling can limit tumor growth and enhance antitumor immunity.Here, we first present the relationships between microbial neurotransmitters and cancer cells mediated by immune cells. Then, we discuss the microbial neurotransmitters recently associated with cancer immunotherapy. Notably, the review emphasizes that neurotransmitter signaling plays a substantial role in cancer immunotherapy as an emerging cancer treatment target by regulating targeted receptors and interfering with the tumor microenvironment.Future studies are required to uncover the antitumor mechanisms of neurotransmitter signaling to develop novel treatment strategies to overcome cancer immunotherapy resistance.
基金：
This work was funded by Dr. Neher’s Biophysics Laboratory for Innovative Drug
Discovery (Grant no. 001/2020/ALC) and regular grants (File no. 0096/2018/A3 &
0111/2020/A3, 0015/2019/AMJ, and 0114/2020/A3) supported by Macao Science and
Technology Development Fund, Macau (S.A.R.) China, 2020 Young Qihuang Scholar funded
by National Administration of Traditional Chinese Medicine, the National Natural Science
Foundation of China (82003779 and 82001995), the Natural Science Foundation of Gansu
Province (20JR10RA010), the Macao Young Scholars Program (AM201926 and
AM2020018), FDCT Funding Scheme for Postdoctoral Researchers of Higher Education Institutions (0017/2021/APD), and the Science, Technology and Innovation Commission of
Shenzhen Municipality (ZDSYS20190902093601675).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|2 区生物学
小类|2 区生化与分子生物学2 区内分泌学与代谢
最新[2025]版：
大类|2 区生物学
小类|2 区生化与分子生物学2 区内分泌学与代谢
第一作者：
第一作者机构：[1]Cancer Center, Faculty of Health Science, University of Macau, Macau (SAR), China. MOE Frontiers Science Center for Precision Oncology, University of Macau, Macau (SAR), China[*1]Ministry of Education Frontiers Science Center for Precision Oncology, Faculty of Health Science, University of Macau, Macau (SAR), China
共同第一作者：
通讯作者：
通讯机构：[1]Cancer Center, Faculty of Health Science, University of Macau, Macau (SAR), China. MOE Frontiers Science Center for Precision Oncology, University of Macau, Macau (SAR), China[2]Dr. Neher’s Biophysics Laboratory for Innovative Drug Discovery and State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China.[*1]Ministry of Education Frontiers Science Center for Precision Oncology, Faculty of Health Science, University of Macau, Macau (SAR), China[*2]State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China
推荐引用方式(GB/T 7714)：
Leung Elaine Lai-Han,Huang Jumin,Zhang Junmin,et al.Novel anticancer strategy by targeting the gut microbial neurotransmitter signaling to overcome immunotherapy resistance[J].Antioxidants & redox signaling.2022,doi:10.1089/ars.2021.0243.
APA：
Leung Elaine Lai-Han,Huang Jumin,Zhang Junmin,Zhang Juanhong,Wang Meifang...&Yao Xiao-Jun.(2022).Novel anticancer strategy by targeting the gut microbial neurotransmitter signaling to overcome immunotherapy resistance.Antioxidants & redox signaling,,
MLA：
Leung Elaine Lai-Han,et al."Novel anticancer strategy by targeting the gut microbial neurotransmitter signaling to overcome immunotherapy resistance".Antioxidants & redox signaling .(2022)
生物学