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The pharmacology, pharmacokinetics, and toxicity of spinosin: A mini review

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收录情况： ◇ SCIE

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机构： [1]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China. [2]Department of Pharmacy, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. [3]Department of pharmacy, GuangDong Women and Children Hospital, Guangzhou, China.

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关键词： spinosin pharmacology pharmacokinetics toxicity Ziziphus jujuba Mill var spinosa

摘要：

Spinosin, a natural flavone-C-glycoside that is mainly isolated from the seeds of Ziziphus jujuba Mill. var. spinosa. It exerts the effects to ameliorate the neurological disorders, such as hypnosis effects, improvement of cognitive function, sedation effects, and anxiolytic effects, as well as anti-melanogenic effect, cardioprotective effects, and anti-cancer activity. However, the insufficient basic research, unclear mechanisms, and poor bioavailability may limit the prospects of spinosin in clinical utilization. In this review, we comprehensively summarized the latest information on the pharmacology, pharmacokinetics, toxicity, and NMR characteristic of spinosin, to evaluate its potential therapeutic for clinical application, hoping to provide some rational perspective for the innovative agent development and usage of spinosin in future.Copyright © 2022 Kuang, She, Ma, Cai, Zhao, Liu and Xu.

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出版当年[2021]版：

大类 | 2 区

医学

小类 | 2 区药学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区药学

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出版当年[2020]版：

Q1 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 PHARMACOLOGY & PHARMACY

影响因子： 4.4 最新[2023版] 5 最新五年平均 5.811 出版当年[2020版] 6.006 出版当年五年平均 4.225 出版前一年[2019版] 5.988 出版后一年[2021版]

第一作者：

第一作者机构： [1]Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.

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