资源类型：
期刊
收录情况：
◇ SCIE
文章类型：
Review
作者：
Hou, Wei[1,2,*1,*2]
*
;
Liu, Bo[3,4,*3,*4]
;
Xu, Hongtao[5,*5]
;
机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou, Peoples R China
[2] Zhejiang Univ Technol, IDD & CB, Hangzhou, Peoples R China
[3] Guangzhou Univ Chinese Med, Clin Med Coll 2, Guangzhou, Peoples R China
[4] Guangzhou Univ Chinese Med, Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Guangzhou, Peoples R China
[5] ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China
出处：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY.2020,189:
ISSN：
0223-5234
关键词：
Tripterygium wilfordii hook F
Celastrol
Medicinal chemistry
Cancer
Inflammatory
Diabetes
Obese
Toxicity
Pharmacology and toxicology
摘要：
Celastrol, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has gained extensive exploration due to its unique structure features and multiple promising biological activities. This review will focus on the structural modifications, structureactivity relationships, pharmacology, and toxicology of celastrol in the past ten years. We hope this review would be helpful to get a better grasp of the progresses in the field and provide constructive suggestions for the further study of celastrol. (C) 2020 Elsevier Masson SAS. All rights reserved
基金：
National Natural Science Foundation of China (NSFC) [21977070, 21907085]
WOS：
WOS:000518700000003
PubmedID：
31991334
中科院(CAS)分区：
出版当年[2019]版：
大类
|
2 区
医学
小类
|
1 区
药物化学
最新[2025]版：
大类
|
2 区
医学
小类
|
1 区
药物化学
JCR分区：
出版当年[2018]版：
Q1
CHEMISTRY, MEDICINAL
最新[2023]版：
Q1
CHEMISTRY, MEDICINAL
影响因子：
6
最新[2023版]
6.1
最新五年平均
4.833
出版当年[2018版]
4.666
出版当年五年平均
4.816
出版前一年[2017版]
5.573
出版后一年[2019版]
第一作者：
Hou, Wei
第一作者机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou, Peoples R China
[2] Zhejiang Univ Technol, IDD & CB, Hangzhou, Peoples R China
[*1]Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou, Peoples R China
[*2]Zhejiang Univ Technol, IDD & CB, Hangzhou, Peoples R China
通讯作者：
Hou, Wei;Liu, Bo;Xu, Hongtao
通讯机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou, Peoples R China
[*1]Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou, Peoples R China
[2] Zhejiang Univ Technol, IDD & CB, Hangzhou, Peoples R China
[*2]Zhejiang Univ Technol, IDD & CB, Hangzhou, Peoples R China
[3] Guangzhou Univ Chinese Med, Clin Med Coll 2, Guangzhou, Peoples R China
[*3]Guangzhou Univ Chinese Med, Clin Med Coll 2, Guangzhou, Peoples R China
[4] Guangzhou Univ Chinese Med, Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Guangzhou, Peoples R China
[*4]Guangzhou Univ Chinese Med, Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Guangzhou, Peoples R China
[5] ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China
[*5]ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China
推荐引用方式(GB/T 7714)：
Hou Wei,Liu Bo,Xu Hongtao.Celastrol: Progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology[J].EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY.2020,189:
医学