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Temporal changes in cyclinD-CDK4/CDK6 and cyclinE-CDK2 pathways: implications for the mechanism of deficient decidualization in an immune-based mouse model of unexplained recurrent spontaneous abortion

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机构： [1]Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China [2]First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin, Heilongjiang, China [3]Zhuhai Hospital of Integrated Traditional Chineseand Western Medicine, Zhuhai, China [4]Hospital of Traditional Chinese Medicineof Qiqihar, Qiqihar, China [5]Zhaoqing City Guangdong Province Hospitalof Traditional Chinese Medicine, Zhaoqing, China [6]Guang’anmen Hospital,China Academy of Chinese Medicine Sciences, Beijing, China

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关键词： Unexplained recurrent spontaneous abortion Decidualization Cell cycle

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Deficient endometrial decidualization has been associated with URSA. However, the underlying mechanism is poorly understood. This study aimed to investigate the temporal cytokine changes and the involvement of CyclinD-CDK4/6 and CyclinE-CDK2 pathways in the regulation of the G1 phase of the cell cycle during decidualization in a murine model of URSA.Serum and decidual tissues of mice were collected from GD4 to GD8. The embryo resorption and abortion rates were observed on GD8 and the decidual tissue status was assessed. In addition, PRL, Cyclin D, CDK6, CDK4, Cyclin E, CDK2 expression in mice were measured.URSA mice showed high embryo resorption rate and PRL, Cyclin D, Cyclin E CDK2, CDK4, CDK6 down-regulation during decidualization. The hyperactivated Cyclin D-CDK4/CDK6 and cyclin E/CDK2 pathways inhibit the decidualization process and leading to deficient decidualization.Insufficient decidualization is an important mechanism of URSA. which is related to the decrease of Cyclin D、Cyclin E、 CDK2、CDK4 and CDK6 in decidualization process of URSA.© 2022. The Author(s).

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出版当年[2021]版：

大类 | 2 区医学

小类 | 2 区生化与分子生物学 2 区细胞生物学 2 区医学：研究与实验

最新[2025]版：

大类 | 2 区

医学

小类 | 2 区生化与分子生物学 2 区细胞生物学 2 区医学：研究与实验

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第一作者机构： [1]Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China

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