高级检索
当前位置: 首页 > 详情页

Troglitazone inhibits hepatic oval cell proliferation by inducing cell cycle arrest through Hippo/YAP pathway regulation.

文献详情

资源类型:
WOS体系:
Pubmed体系:

收录情况: ◇ SCIE

机构: [1]Guangdong Second Provincial General Hospital, 466 Middle Xingang Road, Guangzhou, 510317, Guangdong, People’s Republic of China [2]Affiliated Hospital of Guangdong Medical University, 57 South Renmin Avenue, Zhanjiang, 524001, Guangdong, People’s Republic of China [3]TCM-Integrated Hospital, Southern Medical University, 13 Shiliugang Road, Guangzhou, 510315, Guangdong, People’s Republic of China [4]Shenzhen Longhua District Central Hospital, Jianshe East Road Shenzhen, 518109, Guangdong, People’s Republic of China
出处:
ISSN:

关键词: Cell cycle Hepatic oval cell Hippo pathway Troglitazone

摘要:
Hepatic oval cells have strong proliferation and differentiation capabilities and are activated when chronic liver injury occurs or when liver function is severely impaired. Peroxisome proliferation-activated receptors (PPARs) are ligand-dependent, sequence-specific nuclear transcription factors. PPARγ is closely related to liver diseases (such as liver cancer, liver fibrosis and non-alcoholic fatty liver disease). As the main effector downstream of the Hippo signaling pathway, YAP can activate the hepatic progenitor cell program, and different expression or activity levels of YAP can determine different liver cell fates. We found that troglitazone (TRO), a classic PPARγ activator, can inhibit the growth of hepatic oval cells, and flow cytometry results showed that TRO inhibited the growth of WB-F344 cells by arresting the cells in the G0/1 phase. Western blot results also confirmed changes in G0/1 phase-related protein expression. Further experiments showed that PPARγ agonists induced hepatic oval cell proliferation inhibition and cell cycle G0/1 phase arrest through the Hippo/YAP pathway. Our experiment demonstrated, for the first time, the relationship between PPARγ and the Hippo/YAP pathway in liver oval cells and revealed that PPARγ acts as a negative regulator of liver regeneration by inhibiting the proliferation of oval cells.Copyright © 2021. Published by Elsevier Ltd.

基金:
语种:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2021]版:
大类 | 3 区 医学
小类 | 3 区 胃肠肝病学
最新[2025]版:
大类 | 2 区 医学
小类 | 3 区 胃肠肝病学
JCR分区:
出版当年[2020]版:
Q2 GASTROENTEROLOGY & HEPATOLOGY
最新[2023]版:
Q1 GASTROENTEROLOGY & HEPATOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者:
第一作者机构: [1]Guangdong Second Provincial General Hospital, 466 Middle Xingang Road, Guangzhou, 510317, Guangdong, People’s Republic of China [2]Affiliated Hospital of Guangdong Medical University, 57 South Renmin Avenue, Zhanjiang, 524001, Guangdong, People’s Republic of China
共同第一作者:
通讯作者:
通讯机构: [1]Guangdong Second Provincial General Hospital, 466 Middle Xingang Road, Guangzhou, 510317, Guangdong, People’s Republic of China [3]TCM-Integrated Hospital, Southern Medical University, 13 Shiliugang Road, Guangzhou, 510315, Guangdong, People’s Republic of China [*1]Guangdong Second Provincial General Hospital, 466 Middle Xingang Road, Guangzhou 510317, Guangdong, People’s Republic of China [*2]TCM-Integrated Hospital, Southern Medical University, 13 Shiliugang Road, Guangzhou 510315, Guangdong, People’s Republic of China.
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:2020 今日访问量:0 总访问量:646 更新日期:2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持:重庆聚合科技有限公司 地址:广州市越秀区大德路111号