Stroke incidence and cognitive outcomes of intracranial atherosclerotic stenosis: study protocol for a multicenter, prospective, observational cohort study
机构：[1]Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China[2]Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China[3]Center for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, China[4]Department of Neurology, Jining No. 1 People’s Hospital, Jining, China[5]Department of Neurology, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院[6]Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China[7]Department of Neurology, 920 Hospital of Joint Service Support Force of the People’s Liberation Army, Kunming, China[8]Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China[9]Department of Magnetic resonance, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China[10]Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China[11]Department of Neurology, People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Research Center for Stroke and Neurological Rare Disease, Urumqi, China[12]Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China[13]Department of Encephalopathy, Weifang Traditional Chinese Medicine Hospital, Weifang, China[14]Department of Neurology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, China[15]Department of Neurology, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai, China[16]Department of Neurology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China[17]Department of Neurology, Binzhou People’s Hospital, Binzhou, China[18]Department of Neurology, First Hospital of Qinhuangdao, Qinhuangdao, China[19]Department of Radiology, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo, China浙江大学医学院附属第一医院[20]Department of Neurology, Liuzhou Traditional Chinese Medical Hospital, Liuzhou, China[21]Function Department of Neurology, The People’s Hospital of China Medical University, The People’s Hospital of Liaoning Province, Shenyang, China[22]Department of Neurosurgery, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, China[23]Department of Neurology, Huaihe Hospital of Henan University, Kaifeng, China[24]Department of Neurology, Hebei General Hospital, Shijiazhuang, China[25]Department of Neurology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China[26]Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, China[27]Department of Neurology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China[28]Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China[29]Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, China大连医科大学附属第一医院[30]Department of Neurology, Zhongshan Hospital, Dalian University, Dalian, China[31]Department of Neurology, Chengde Central Hospital, Chengde, China[32]The Third Department of Neurology, Baoding First Central Hospital, Baoding, China[33]Department of Neurology, Wuhu No. 1 People’s Hospital, Wuhu, China[34]Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China[35]Department of Neurology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, China[36]Department of Neurology, Jiaozuo People’s Hospital, Jiaozuo, China[37]Department of Neurology, People’s Hospital of Ningxia Hui Autonomous Region, Yinchuan, China[38]Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院[39]Department of Neurology, Chongqing University Jiangjin Hospital, Chongqing, China[40]Department of Neurology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China[41]Department of Neurology, Tongde Hospital of Zhejiang Province, Hangzhou, China[42]Department of Neurology, The Affiliated Hospital of Northwest University, Xi’an No. 3 Hospital, Xi’an, China[43]Department of Neurology, Liaoning province Benxi Central Hospital, Benxi, China[44]Department of Neurology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China[45]Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan, China[46]Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan, China[47]Department of neurology, Tangshan Gongren Hospital, Tangshan, China[48]Department of Neurology, Northern Jiangsu People’s Hospital, Jiangsu, China江苏省人民医院[49]Department of Neurology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China[50]Department of Neurology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, China[51]Department of neurology, People’s Hospital of Jiangxi province and The First Affiliated Hospital of Nanchang Medical College, Nanchang, China[52]Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China重庆医科大学附属第一医院[53]Department of Neurology, Beijing Luhe Hospital, Capital Medical University, Beijing, China[54]Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China[55]Department of MRI, Shengli Oilfield Central Hospital, Shandong, China[56]Department of Neurology, Daqing People’s Hospital, Daqing, China[57]Department of Neurology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China[58]Department of Neurointervention, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing, China[59]Department of Neurology, Binzhou Central Hospital, Binzhou, China[60]Department of Neurology, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Nanchang, China
Background: Intracranial atherosclerotic stenosis (ICAS) is one of the leading causes of stroke worldwide. Current diagnostic evaluations and treatments remain insufficient to assess the vulnerability of intracranial plaques and reduce the recurrence of stroke in symptomatic ICAS. On the other hand, asymptomatic ICAS is associated with an increased risk of cognitive impairment. The pathogenesis of ICAS related cognitive decline is largely unknown. The aim of SICO-ICAS study (stroke incidence and cognitive outcomes of ICAS) is to elucidate the pathophysiology of stroke and cognitive impairment in ICAS population, comprehensively evaluating the complex interactions among life-course exposure, genomic variation, vascular risk factors, cerebrovascular burden and coexisting neurodegeneration. Methods: SICO-ICAS is a multicenter, prospective, observational cohort study. We aim to recruit 3,000 patients with symptomatic or asymptomatic ICAS (> 50% or occlusion) who will be followed up for >= 12 months. All participants will undergo pre-designed magnetic resonance imaging packages, blood biomarkers testing, as well as detailed cognitive domains assessment. All participants will undergo clinical visits every 6 months and telephone interviews every 3 months. The primary outcome measurement is ischemic stroke or cognitive impairment within 12 months after enrollment. Discussion: This study will establish a large prospective ICAS cohort, hopefully discover new biomarkers associated with vulnerable intracranial plaques, identify subjects at high risk for incident ischemic stroke or cognitive impairment, and eventually propose a precise diagnostic and treatment strategy for ICAS population.
基金：
Non-profit Central Research Institute Fund of Chinese Academy of MedicalSciences [2020-RC320-001]; National Science Fund for Distinguished Young Scholars [82025013]
第一作者机构：[1]Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China[*1]Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuaifuyuan1, Dongcheng District, Beijing 100730, China
推荐引用方式(GB/T 7714)：
Qianqian Si,Yuming Teng,Caiyan Liu,et al.Stroke incidence and cognitive outcomes of intracranial atherosclerotic stenosis: study protocol for a multicenter, prospective, observational cohort study[J].ANNALS OF TRANSLATIONAL MEDICINE.2022,10(16):doi:10.21037/atm-22-3570.
APA：
Qianqian Si,Yuming Teng,Caiyan Liu,Weizhuang Yuan,Xiaoyuan Fan...&Weihai Xu.(2022).Stroke incidence and cognitive outcomes of intracranial atherosclerotic stenosis: study protocol for a multicenter, prospective, observational cohort study.ANNALS OF TRANSLATIONAL MEDICINE,10,(16)
MLA：
Qianqian Si,et al."Stroke incidence and cognitive outcomes of intracranial atherosclerotic stenosis: study protocol for a multicenter, prospective, observational cohort study".ANNALS OF TRANSLATIONAL MEDICINE 10..16(2022)
