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Ultrasound-mediated blood-brain barrier opening: An effective drug delivery system for theranostics of brain diseases

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Wang Jieqiong[1] * ; Li Zhenzhou[2] * ; Pan Min[3] ; Fiaz Muhammad[4] ; Hao Yongsheng[5] ; Yan Yiran[6] ; Sun Litao[7,*2] ; Yan Fei[5,*1] ;
机构： [1]Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 201206, China [2]Department of Ultrasound, The Second People’s Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University, Shenzhen 518061, China [3]Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen 518034, China [4]Department of Radiology, Azra Naheed Medical College, Lahore, Pakistan [5]Center for Cell and Gene Circuit Design, CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China [6]Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, China [7]Cancer Center, Department of Ultrasound Medicine, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, Zhejiang 310014, China
出处：
DOI： 10.1016/j.addr.2022.114539
ISSN：

关键词： Blood-brain barrier Ultrasound contrast agents Focused ultrasound Cavitation Drug delivery Theranostics

摘要：
Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases. Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently open the BBB, providing a potential strategy for drug delivery across the BBB into the brain. Nowadays, taking advantage of this technology, many therapeutic agents, such as antibodies, growth factors, and nanomedicine formulations, are intensively investigated across the BBB into specific brain regions for the treatment of various brain diseases. Several preliminary clinical trials also have demonstrated its safety and good tolerance in patients. This review gives an overview of the basic mechanisms, ultrasound contrast agents, evaluation or monitoring methods, and medical applications of FUS-mediated BBB opening in glioblastoma, Alzheimer's disease, and Parkinson's disease.Copyright © 2022 Elsevier B.V. All rights reserved.

基金：
This research is supported by the National Key R&D Program of China (2020YFA0908800), National Natural Science Foundation of China (81871376, 81660381), Guangdong Innovation Platform of Translational Research for Cerebrovascular Diseases, and Shenzhen Science and Technology Innovation Committee (Grant No. JCYJ20190812171820731, JCYJ20170412171856582, JCYJ201805 07182420114).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 1 区 医学
小类 | 1 区 药学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 药学
JCR分区：
出版当年[2020]版：
Q1 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 201206, China
共同第一作者：
通讯作者：
通讯机构： [5]Center for Cell and Gene Circuit Design, CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China [7]Cancer Center, Department of Ultrasound Medicine, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, Zhejiang 310014, China [*1]1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen 518055, China [*2]158 Shangtang Road, Gongshu District, Hangzhou, Zhejiang 310014, China
推荐引用方式(GB/T 7714)：
Wang Jieqiong,Li Zhenzhou,Pan Min,et al.Ultrasound-mediated blood-brain barrier opening: An effective drug delivery system for theranostics of brain diseases[J].ADVANCED DRUG DELIVERY REVIEWS.2022,190:doi:10.1016/j.addr.2022.114539.
APA：
Wang Jieqiong,Li Zhenzhou,Pan Min,Fiaz Muhammad,Hao Yongsheng...&Yan Fei.(2022).Ultrasound-mediated blood-brain barrier opening: An effective drug delivery system for theranostics of brain diseases.ADVANCED DRUG DELIVERY REVIEWS,190,
MLA：
Wang Jieqiong,et al."Ultrasound-mediated blood-brain barrier opening: An effective drug delivery system for theranostics of brain diseases".ADVANCED DRUG DELIVERY REVIEWS 190.(2022)

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