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The Synergism of Natural Compounds and Conventional Therapeutics against Colorectal Cancer Progression and Metastasis

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机构: [1]Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, 999078 Macao, China. [2]College of Pharmacy, Hangzhou Normal University, 311121 Hangzhou, Zhejiang, China. [3]Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, 310015 Hangzhou, Zhejiang, China. [4]The First Clinical Medical College of Nanjing University of Chinese Medicine, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, 210023 Nanjing, Jiangsu, China. [5]Center for Medical Research and Innovation, the First Hospital of Hunan University of Chinese Medicine, 410000 Changsha, Hunan, China. [6]Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, 311121 Hangzhou, Zhejiang, China. [7]Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, 311121 Hangzhou, Zhejiang, China. [8]Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, 510000 Guangzhou, Guangdong, China. [9]Zhuhai MUST Science and Technology Research Institute, 519000 Zhuhai, Guangdong, China. [10]Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, 519020 Zhuhai, Guangdong, China.
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关键词: natural compounds; conventional therapeutics; colorectal cancer; progression and metastasis; drug combination

摘要:
Cancer progression and metastases are the leading causes of poor outcomes in patients with colon cancer. Colon cancer metastasis is a multigene, multistep, multistage complex process in which target genes, microRNAs, epithelial-stromal transformation, tumour stem cells, the tumour microenvironment, and various cell signalling pathways are implicated in the progression and metastasis of colon cancer. Although conventional therapies have made significant advances in treating the progression and metastasis of colorectal cancer, they have failed to improve survival outcomes. Natural compounds may have more significant potential in preventing and treating colon cancer. Active natural compounds exert their antitumor effects by inducing tumour cell differentiation, promoting tumour cell apoptosis, inhibiting tumour vascular growth, and regulating immunity. Natural compounds, combined with conventional therapies, can target mutant genes and various cellular signalling pathways, inhibit epithelial-stromal transformation, and improve the tumour microenvironment to inhibit tumour progression and metastasis. The synergism of natural compounds and conventional therapeutics has the potential to become a promising therapy for treating colorectal cancer progression and metastases.© 2022 The Author(s). Published by IMR Press.

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大类 | 4 区 生物学
小类 | 4 区 生化与分子生物学 4 区 细胞生物学
第一作者:
第一作者机构: [1]Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, 999078 Macao, China. [2]College of Pharmacy, Hangzhou Normal University, 311121 Hangzhou, Zhejiang, China. [3]Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, 310015 Hangzhou, Zhejiang, China.
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通讯机构: [1]Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, 999078 Macao, China. [2]College of Pharmacy, Hangzhou Normal University, 311121 Hangzhou, Zhejiang, China. [3]Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, 310015 Hangzhou, Zhejiang, China. [6]Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, 311121 Hangzhou, Zhejiang, China. [7]Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, 311121 Hangzhou, Zhejiang, China. [8]Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, 510000 Guangzhou, Guangdong, China. [9]Zhuhai MUST Science and Technology Research Institute, 519000 Zhuhai, Guangdong, China. [10]Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, 519020 Zhuhai, Guangdong, China.
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