个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

Akkermansia muciniphila ameliorates chronic kidney disease interstitial fibrosis via the gut-renal axis

| 认领 | 导出 | |

文献详情

资源类型：
Pubmed体系：
作者：
Pei Tingting[1] * ; Hu Rong[1] ; Wang Fujing[1] ; Yang Sixia[1] ; Feng Haitong[1] ; Li Qiye[1] ; Zhang Jiaxing[1] ; Yan Shihua[1] ; Ju Liliang[1] ; He Zhuoen[1] ; Han Zhongxiao[1] ; Yang Aicheng[2] ; Xiao Wei[1,4,*1] ; Yun Ma[3] ; Wang Mingqing[1] ;
机构： [1]Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China [2]Nephropathy Center, The Affiliated Jiangmen TCM Hospital, Jinan University, Jiangmen, 529030, China [3]Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China [4]Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education, Guangdong Pharmaceutical University, Guangzhou, Guang Dong, 510006, China
出处：
DOI： 10.1016/j.micpath.2022.105891
ISSN：

关键词： Chronic kidney disease Intestinal barrier Akkermansia muciniphila Intestinal microecology Renal interstitial fibrosis

摘要：
Chronic kidney disease (CKD) affects approximately 10% of the global population. The abundance of Akkermansia muciniphila (AKK) is significantly reduced in CKD patients.This study investigated the effects of AKK bacteria on kidney damage and the renal interstitium in rats with CKD.CKD model 5/6 nephrectomy rats were used. CKD rats were supplemented with AKK (2 × 108 cfu/0.2 mL) for 8 weeks.AKK administration significantly suppressed epithelial-mesenchymal transition (EMT), and high-throughput 16S rRNA pyrosequencing showed that AKK supplementation restored the disordered intestinal microecology in CKD rats. AKK also enhanced the intestinal mucosal barrier function. AKK may regulate the intestinal microecology and reduce renal interstitial fibrosis by enhancing the abundance of probiotics and reducing damage to the intestinal mucosal barrier.The results suggest that AKK administration could be a novel therapeutic strategy for treating renal fibrosis and CKD.Copyright © 2022. Published by Elsevier Ltd.

基金：
This work was supported by the National Natural Science Foundation of China (81973804, 81673890,82004336,81774035, 82174322), Natural Science Foundation of Guangdong Province (2017A030313750, 2022A1515011405), Innovation team of chronic kidney disease with integrated traditional Chinese and Western Medicine (2019KCXTD014), and Guangdong Provincial Administration of traditional Chinese Medicine (20200505160744).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 医学
小类 | 3 区 免疫学 3 区 微生物学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 免疫学 3 区 微生物学
第一作者：
第一作者机构： [1]Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China
通讯作者：
通讯机构： [1]Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China [4]Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education, Guangdong Pharmaceutical University, Guangzhou, Guang Dong, 510006, China [*1]Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education, Guangdong Pharmaceutical University, Guangzhou, Guang Dong, 510006, China.
推荐引用方式(GB/T 7714)：
Pei Tingting,Hu Rong,Wang Fujing,et al.Akkermansia muciniphila ameliorates chronic kidney disease interstitial fibrosis via the gut-renal axis[J].Microbial pathogenesis.2022,105891.doi:10.1016/j.micpath.2022.105891.
APA：
Pei Tingting,Hu Rong,Wang Fujing,Yang Sixia,Feng Haitong...&Wang Mingqing.(2022).Akkermansia muciniphila ameliorates chronic kidney disease interstitial fibrosis via the gut-renal axis.Microbial pathogenesis,,
MLA：
Pei Tingting,et al."Akkermansia muciniphila ameliorates chronic kidney disease interstitial fibrosis via the gut-renal axis".Microbial pathogenesis .(2022):105891

相关文献

[1]Bacteroides plebeius improves muscle wasting in chronic kidney disease by modulating the gut-renal muscle axis [2]Asperulosidic Acid Ameliorates Renal Interstitial Fibrosis via Removing Indoxyl Sulfate by Up-Regulating Organic Anion Transporters in a Unilateral Ureteral Obstruction Mice Model [3]SAA1 is transcriptionally activated by STAT3 and accelerates renal interstitial fibrosis by inducing endoplasmic reticulum stress. [4]Ethanol extract of gardenia fruit alleviates renal interstitial fibrosis induced by unilateral ureteral obstruction in rats. [5]Corrigendum: Akkermansia muciniphila suppressing nonalcoholic steatohepatitis associated tumorigenesis through CXCR6+ natural killer T cells [6]Akkermansia muciniphila suppressing nonalcoholic steatohepatitis associated tumorigenesis through CXCR6+ natural killer T cells [7]丹参注射液对梗阻性肾病梗阻解除后肾间质纤维化的影响 [8]Rhubarb Enema Improved Colon Mucosal Barrier Injury in 5/6 Nephrectomy Rats May Associate With Gut Microbiota Modification [9]Corrigendum: Akkermansia muciniphila suppressing nonalcoholic steatohepatitis associated tumorigenesis through CXCR6+ natural killer T cells [10]A chronic kidney disease patient awareness questionnaire: Development and validation

资源点击量：2018 今日访问量：0 总访问量：645 更新日期：2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持：重庆聚合科技有限公司 地址：广州市越秀区大德路111号