机构：[1]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou Higher Education Mega Center, Guangzhou, China.广东省中医院[2]Institute of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou, China.[3]School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Buyang-huanwu decoction (BHD) is a classic prescription that has great potential to be developed into antifatigue functional food. It may activate blood circulation to relieve fatigue in some clinical cases by unclear mechanisms. In this study, a metabolomics approach was conducted to investigate the antifatigue mechanism of BHD. The murine fatigue model was established in rats by endurance swimming, and hemorheology, blood biochemistry, and ultraperformance liquid chromatography-mass spectrometry-based metabolomics were conducted on serum samples. The rate of weight gain, hemorheological parameters, and serum creatine kinase activities were significantly altered in model rats and they returned to a normal level after BHD administration. Pattern recognition screened 18 potential biomarkers, which are mainly involved in glycerophospholipid, arachidonic acid, and cholesterol metabolisms. The results demonstrate that the antifatigue mechanism of BHD is mainly related to the function of enhancing nerve conduction, relieving inflammation and regulating cholesterol metabolism and energy metabolism.
基金：
Guangdong Provincial Key
Laboratory of Chinese Medicine for Prevention and Treatment
of Refractory Chronic Disease (No. 2018B030322012),
Guangdong Provincial Key Laboratory of Pathogenesis and
Therapy of Traditional Chinese Medicine Open Project Fund
(No. AAF111111A08), the Key Project of National Natural
Science Foundation of China (No. 81830117).
第一作者机构：[1]The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou Higher Education Mega Center, Guangzhou, China.
通讯作者：
通讯机构：[2]Institute of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou, China.[3]School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.[*1]School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Minhang District, Shanghai 200240, China[*2]Institute of Traditional Chinese Medicine, Guangdong Pharmaceutical University, No. 280 Outer Ring East Road, Guangzhou Higher Education Mega Center, Guangzhou, Guangdong 510006, China
推荐引用方式(GB/T 7714)：
Li Shasha,Zhan Min,Yan Shikai,et al.The Antifatigue Mechanism of Buyang-huanwu Decoction as Revealed by Serum Metabolomics in an Endurance Swimming Rat Model[J].JOURNAL OF MEDICINAL FOOD.2022,25(11):1038-1049.doi:10.1089/jmf.2022.K.0014.
APA：
Li, Shasha,Zhan, Min,Yan, Shikai&Xiao, Xue.(2022).The Antifatigue Mechanism of Buyang-huanwu Decoction as Revealed by Serum Metabolomics in an Endurance Swimming Rat Model.JOURNAL OF MEDICINAL FOOD,25,(11)
MLA：
Li, Shasha,et al."The Antifatigue Mechanism of Buyang-huanwu Decoction as Revealed by Serum Metabolomics in an Endurance Swimming Rat Model".JOURNAL OF MEDICINAL FOOD 25..11(2022):1038-1049
