详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

Novel biomimetic mesoporous silica nanoparticle system possessing targetability and immune synergy facilitates effective solid tumor immuno-chemotherapy

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Orthopedics, The First Affiliated Hospital and The Fifth Affiliated Hospital, Jinan University, Guangzhou, China [2]Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen, China [3]Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, China [4]Department of Neurosurgery, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated with Jinan University), Jinan University, Zhuhai, China [5]The Biomedical Translational Research Institute, Jinan University Faculty of Medical Science, Jinan University, Guangzhou, China [6]The Affiliated Hospital (Jiangmen Traditional Chinese Medicine Hospital), Jinan University, Guangzhou, China [7]School of Food Science and Engineering, South China University of Technology, Guangzhou, China [8]State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi, China

出处：

DOI：

ISSN：

关键词： Breast tumor Tumor targetability Immunoregulation Mesoporous silica CD80 Immunotherapy

摘要：

New strategies that enhance both the targetability of chemotherapy drugs and the synergistic effects of chemotherapy and immunotherapy are urgently needed for efficacious solid tumor therapy. In this study, a novel biomimetic nanoparticle system possessing the properties of tumor targeting and immune synergy was designed to meet these requirements. Mesoporous silica nanoparticles loaded with the chemotherapeutic drug doxorubicin (DOX) were coated with cell membranes modified by glycosylphosphatidylinositol (GPI)-anchored anti-HER2 single chain variable fragment (scFv) and the GPI-anchored co-stimulatory molecule CD80 (to promote solid tumor-targeted chemotherapy and cooperated immunotherapy, respectively). The impact of the nanotherapeutic system on both tumor-targeted chemotherapy and cellular immune response was investigated through in vitro and in vivo experiments. The results show that the novel biomimetic therapeutic system effectively promoted antitumor efficiency in vitro and in vivo. In addition, this therapeutic system further enhanced antitumor capacity by increasing CD8+ T cell activation and cytokine production and reducing myeloid-derived suppressor cell (MDSC) levels in tumors.Copyright © 2022. Published by Elsevier B.V.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2021]版：

无

最新[2025]版：

大类 | 2 区

医学

小类 | 2 区材料科学：生物材料

第一作者：

第一作者机构： [1]Department of Orthopedics, The First Affiliated Hospital and The Fifth Affiliated Hospital, Jinan University, Guangzhou, China

共同第一作者：

通讯作者：

通讯机构： [1]Department of Orthopedics, The First Affiliated Hospital and The Fifth Affiliated Hospital, Jinan University, Guangzhou, China [2]Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen, China [3]Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, China [7]School of Food Science and Engineering, South China University of Technology, Guangzhou, China [*1]Department of Orthopedics, The First Affiliated Hospital and The Fifth Affiliated Hospital, Jinan University, Guangzhou, China.Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, China. [*2]Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen, China [*3]Department of Orthopedics, The First Affiliated Hospital and The Fifth Affiliated Hospital, Jinan University, Guangzhou, China. [*4]School of Food Science and Engineering, South China University of Technology, Guangzhou, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

Novel biomimetic mesoporous silica nanoparticle system possessing targetability and immune synergy facilitates effective solid tumor immuno-chemotherapy

文献详情

相关文献