机构：[1]Guangzhou Women And Children's Medical Center, Guangzhou, Guangdong Province, China.[2]Shantou University Medical College, Shantou, Guangdong Province, China.[3]School of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.[4]The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
In recent years, local antibiotic-loaded bone substitutes (ALBS) has been used increasingly in the treatment of diabetic foot infection (DFI). The meta-analysis aimed to analyze the efficacy of ALBS on patients with moderate to severe DFI (with or without osteomyelitis). With an appropriate search strategy, 7 studies were selected for analysis (2 RCTs and 5 cohort studies). The result showed that the application of ALBS effectively reduced the length of hospital stay (WMD -5.55; 95%CI -9.85 to -1.26; P=0.01), the recurrence rates (RR 0.33; 95%CI 0.15 to 0.69; P=0.003) and the mortality rates (RR 0.22; 95%CI 0.06 to 0.82; P=0.02). Compared to the control groups, however, there was no difference in healing rates (RR 1.06; 95%CI 0.96 to 1.18; P=0.26), healing time (WMD -1.44; 95%CI -3.37 to -0.49; P=0.14), the number of debridement (WMD -1.98; 95%CI -4.08 to 0.12; P=0.06) and major amputation rates (RR 0.76; 95%CI 0.35 to 1.61; P=0.47).The ALBS appears to have some beneficial effects as an adjunct to standard surgery in the treatment of DFI with or without osteomyelitis, as it reduces recurrence rates, mortality rates, and length of hospital stay, but there was no statistically significant difference in enhancing wound healing.This article is protected by copyright. All rights reserved.
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外文
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中科院(CAS)分区：
出版当年[2021]版：
大类|3 区医学
小类|3 区细胞生物学3 区皮肤病学3 区医学：研究与实验3 区外科
最新[2025]版：
大类|3 区医学
小类|3 区细胞生物学3 区皮肤病学3 区医学：研究与实验3 区外科
第一作者：
第一作者机构：[1]Guangzhou Women And Children's Medical Center, Guangzhou, Guangdong Province, China.[2]Shantou University Medical College, Shantou, Guangdong Province, China.
共同第一作者：
通讯作者：
通讯机构：[4]The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.[*1]Wound care Clinic,The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, 515041,China.
推荐引用方式(GB/T 7714)：
Lin Xinyi,Wu Yan,Huang Hong,et al.Antibiotic-loaded bone substitutes therapy in the management of the moderate to severe diabetic foot infection: a meta-analysis[J].Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.2022,doi:10.1111/wrr.13061.
APA：
Lin Xinyi,Wu Yan,Huang Hong,Peng Ruihan,Huang FuHua...&Chen WenZhuan.(2022).Antibiotic-loaded bone substitutes therapy in the management of the moderate to severe diabetic foot infection: a meta-analysis.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society,,
MLA：
Lin Xinyi,et al."Antibiotic-loaded bone substitutes therapy in the management of the moderate to severe diabetic foot infection: a meta-analysis".Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society .(2022)
