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Glutamatergic neurotransmission is affected by low-frequency repetitive transcranial magnetic stimulation over the supplemental motor cortex of patients with obsessive-compulsive disorder

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收录情况： ◇ SCIE ◇ SSCI

作者：
Wang Jian[1,2] * ; Hua Guanmin[5] ; Wang Shibin[2] ; Guo Guangquan[2] ; Quan Dongming[2] ; Yao Siyu[2] ; Zheng Huirong[1,2,3,4,*1] ;
机构： [1]School of Medicine, South China University of Technology, Guangzhou, China [2]Guangdong Mental Health Center, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China [3]The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China [4]Shantou University Medical College, Shantou, China [5]Guangzhou Yuexiu District Hospital of Chinese Medicine, Guangzhou, China
出处：
DOI： 10.1016/j.jad.2023.01.064
ISSN：

关键词： Obsessive-compulsive disorder Transcranial magnetic stimulation Magnetic resonance spectroscopy Brain metabolites

摘要：
In obsessive-compulsive disorder (OCD), glutamatergic neurotransmission dysfunction played key roles in pathophysiology. The current research assessed changes of neurometabolites in the bilateral striatum of OCD patients receiving low-frequency repetitive transcranial magnetic stimulation (rTMS) using 1H proton magnetic resonance spectroscopy (1H-MRS).52 OCD patients were divided into rTMS treatment group (29) and the control group (medication only) (22). The levels of neurometabolites in the bilateral striatum of patients with OCD were measured using MRS before and after treatment. All participants were taking medication prior to the treatment and the process.Following rTMS treatment, Yale-Brown Obsessive-Compulsive Scale (YBOCS) score was significantly decreased in the rTMS group compared with the control group. Glutamate (Glu) and glutamate and glutamine complexes (Glx) in the bilateral striatum of the rTMS treatment response group increased significantly with the improvement of OCD. Glu in the bilateral striatum and Glx in the right striatum were positively correlated with compulsion after the treatment.The physiopathological mechanism of OCD may be related to the glutamatergic dysfunction, and the low-frequency repetitive transcranial magnetic stimulation applied to the supplementary motor area can improve OCD symptoms by modulating glutamatergic levels in the bilateral striatum of patients with OCD.Copyright © 2023 Elsevier B.V. All rights reserved.

基金：
This work was supported by the Natural Science Foundation of Guangdong Province (2018A030313989), the Science and Technology Program of Guangzhou (201804010331), the Natural Science Foundation of Guangdong Province (2021A1515011431), and the Project launched by the National Natural Science Foundation of China (8207120173).
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 精神病学 2 区 临床神经病学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 临床神经病学 2 区 精神病学
JCR分区：
出版当年[2021]版：
Q1 CLINICAL NEUROLOGY Q1 PSYCHIATRY
最新[2023]版：
Q1 CLINICAL NEUROLOGY Q1 PSYCHIATRY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]School of Medicine, South China University of Technology, Guangzhou, China [2]Guangdong Mental Health Center, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
通讯作者：
通讯机构： [1]School of Medicine, South China University of Technology, Guangzhou, China [2]Guangdong Mental Health Center, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China [3]The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China [4]Shantou University Medical College, Shantou, China [*1]Guangdong Mental Health Center, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 123 Huifu Xi Road, Guangzhou 510080, China
推荐引用方式(GB/T 7714)：
Wang Jian,Hua Guanmin,Wang Shibin,et al.Glutamatergic neurotransmission is affected by low-frequency repetitive transcranial magnetic stimulation over the supplemental motor cortex of patients with obsessive-compulsive disorder[J].JOURNAL OF AFFECTIVE DISORDERS.2023,325:762-769.doi:10.1016/j.jad.2023.01.064.
APA：
Wang Jian,Hua Guanmin,Wang Shibin,Guo Guangquan,Quan Dongming...&Zheng Huirong.(2023).Glutamatergic neurotransmission is affected by low-frequency repetitive transcranial magnetic stimulation over the supplemental motor cortex of patients with obsessive-compulsive disorder.JOURNAL OF AFFECTIVE DISORDERS,325,
MLA：
Wang Jian,et al."Glutamatergic neurotransmission is affected by low-frequency repetitive transcranial magnetic stimulation over the supplemental motor cortex of patients with obsessive-compulsive disorder".JOURNAL OF AFFECTIVE DISORDERS 325.(2023):762-769

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