机构：[1]Department of Radiology, Guangdong Provincial Traditional Chinese Medicine Hospital and Postdoctoral Mobile Research Station of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China大德路总院影像科大德路总院放射科广东省中医院[2]Department of Neurology, Guangdong Provincial Traditional Chinese Medicine Hospital and Postdoctoral Mobile Research Station of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China广东省中医院[3]School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China
AIM: To investigate the normal hepatic magnetic resonance spectroscopy findings choline/lipid2 (Cho/Lip2) associated with age and body mass index (BMI). METHODS: A total of 58 single-voxel proton spectra of the liver were acquired at 3.0 T using the eight-channel phased array abdominal coil as the receiver coil. Consecutive stacks of breath-hold spectra were acquired using the point resolved spectroscopy technique at a short echo time of 30 ms and a repetition time of 1500 ms. The spectra were processed with the SAGE software package. Areas and heights for metabolite resonance were obtained. Student's t test for unpaired data was used for comparisons of shimming, Cho/Lip2, and lipid content. RESULTS: There were significant negative correlations between the Cho/Lip2 peak height ratios and BMI (r = -0.615) and age (r = -0.398) (all P < 0.01). Compared with the high-BMI group, the low-BMI group was younger (39.1 +/- 13.0 years vs 47.6 +/- 8.5 years, t = -2.954, P = 0.005); had better water suppression (93.4% +/- 1.4% vs 85.6% +/- 11.6%, t = 2.741, P = 0.014); had higher Cho/Lip2 peak heights ratio (0.2 +/- 0.14 vs 0.05 +/- 0.04, t = 6.033, P < 0.000); and had lower lipid content (0.03 +/- 0.08 vs 0.29 +/- 0.31, t = -3.309, P = 0.004). Compared with the older group, the younger group had better shimming effects (17.1 +/- 3.6 Hz vs 22.0 +/- 6.8 Hz, t = -2.919, P = 0.008); higher Cho/Lip2 peak heights ratios (0.03 +/- 0.05 vs 0.09 +/- 0.12, t = 2.4, P = 0.020); and lower lipid content (0.05 +/- 0.11 vs 0.23 +/- 0.32, t = -2.337, P = 0.031). Compared with the low-choline peak group, the high-choline peak group had lower lipid content (0.005 +/- 0.002 vs 0.13 +/- 0.23, t = -3.796, P < 0.000); lower BMI (19.6 +/- 2.4 vs 23.9 +/- 3.0, t = -4.410, P < 0.000); and younger age (34.7 +/- 10.0 years vs 43.2 +/- 12.5 years, t = -2.088, P = 0.041). CONCLUSION: Lipid accumulation could result from the increased fat in the body depending on age and BMI. Lipid can mask the resonance signal of choline. (C) 2013 Baishideng. All rights reserved.
第一作者机构：[1]Department of Radiology, Guangdong Provincial Traditional Chinese Medicine Hospital and Postdoctoral Mobile Research Station of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China[*1]Department of Radiology, Guangdong Provincial Traditional Chinese Medicine Hospital and Postdoctoral Mobile Research Station of Guangzhou University of Traditional Chinese Medicine, 111 Da De Lu, Guangzhou 510120, Guangdong Province, China
通讯作者：
通讯机构：[1]Department of Radiology, Guangdong Provincial Traditional Chinese Medicine Hospital and Postdoctoral Mobile Research Station of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China[*1]Department of Radiology, Guangdong Provincial Traditional Chinese Medicine Hospital and Postdoctoral Mobile Research Station of Guangzhou University of Traditional Chinese Medicine, 111 Da De Lu, Guangzhou 510120, Guangdong Province, China
推荐引用方式(GB/T 7714)：
Li Xu,Bo Liu,Yan Huang,等.3.0 T proton magnetic resonance spectroscopy of the liver: Quantification of choline[J].WORLD JOURNAL OF GASTROENTEROLOGY.2013,19(9):1472-1477.
