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Yishen Huashi granule modulated lipid metabolism in diabetic nephropathy via PI3K/AKT/mTOR signaling pathways

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资源类型：
Pubmed体系：
作者：
Zhao Tingting[1] * ; Xiang Qian[1] * ; Lie Beifeng[2] * ; Chen Deqi[2] ; Li Minyi[2] ; Zhang Xi[1] ; Yang Junzheng[2] ; He Bao[2] ; Zhang Wei[1] ; Dong Ruixue[3] ; Liu Yadi[1] ; Gu Junling[1] ; Zhu Quan[2] ; Yao Yijing[1] ; Duan Tingting[2] ; Li Zhenghai[2] ; Xu Youhua[1,3,4,5,*1] ;
机构： [1]Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macao, PR China. [2]Institute of Consun Co. for Chinese Medicine in Kidney Diseases, Guangdong Consun Pharmaceutical Group, Dongpeng Road 71, Guangzhou, PR China. [3]School of Pharmacy, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macao, PR China. [4]Department of Endocrinology, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, PR China. [5]Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute, Hengqin, Zhuhai, PR China.
出处：
DOI： 10.1016/j.heliyon.2023.e14171
ISSN：

关键词： Diabetic nephropathy Lipid metabolism Yishen Huashi Intestinal-liver axis

摘要：
Diabetic nephropathy (DN) is the primary cause of end-stage renal disease worldwide. Although etiology for DN is complex and still needs to be fully understood, lipid metabolism disorder is found to play a role in it. Previously, we found Yishen Huashi (YSHS) granule could inhibit diabetic damage and reduce level of microalbuminuria (mALB) in DN animals. To explore its role and mechanism in lipid metabolism under DN settings, this study was designed.DN rats were induced by streptozotocin (STZ), HepG2 and CaCO2 cells were applied for in vitro study. Hematoxylin-Eosin (HE), periodic acid-Schiff (PAS) staining, and Transmission Electron Microscopy (TEM) were applied for histological observation; 16s Sequencing was used for intestinal microbiota composition analysis; western blotting (WB) and immunofluorescence were carried out for molecular biological study, and enzyme-linked immunosorbent assay (ELISA) was used for lipid determination.YSHS administration significantly reduced levels of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL-C), while increased level of high-density lipoprotein (HDL-C); meanwhile, histological changes and steatosis of the liver was ameliorated, integrity of the intestinal barrier was enhanced, and dysbacteriosis within intestinal lumen was ameliorated. Mechanism study found that YSHS modulated mitophagy within hepatocytes and inhibited mTOR/AMPK/PI3K/AKT signaling pathway.In conclusion, we found in the present study that YSHS administration could ameliorate lipid metabolism disorder in DN animals, and its modulation on intestinal-liver axis played a significant role in it.© 2023 The Authors.

基金：
Science and Technology Development Fund of Macau [0025/2019/AGJ & 0055/2019/AMJ].Department of Science and Technology of Guangdong Province [2020A050515013].
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 4 区 综合性期刊
小类 | 4 区 综合性期刊
最新[2025]版：
大类 | 4 区 综合性期刊
小类 | 4 区 综合性期刊
第一作者：
第一作者机构： [1]Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macao, PR China.
共同第一作者：
通讯作者：
通讯机构： [1]Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macao, PR China. [3]School of Pharmacy, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macao, PR China. [4]Department of Endocrinology, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, PR China. [5]Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute, Hengqin, Zhuhai, PR China. [*1]Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macao, PR China.
推荐引用方式(GB/T 7714)：
Zhao Tingting,Xiang Qian,Lie Beifeng,et al.Yishen Huashi granule modulated lipid metabolism in diabetic nephropathy via PI3K/AKT/mTOR signaling pathways[J].Heliyon.2023,9(3):e14171.doi:10.1016/j.heliyon.2023.e14171.
APA：
Zhao Tingting,Xiang Qian,Lie Beifeng,Chen Deqi,Li Minyi...&Xu Youhua.(2023).Yishen Huashi granule modulated lipid metabolism in diabetic nephropathy via PI3K/AKT/mTOR signaling pathways.Heliyon,9,(3)
MLA：
Zhao Tingting,et al."Yishen Huashi granule modulated lipid metabolism in diabetic nephropathy via PI3K/AKT/mTOR signaling pathways".Heliyon 9..3(2023):e14171

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