机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China[2]Department of Endocrinology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China[3]Touchstone Diabetes Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
To evaluate the protective effect of catalpol against diabetic nephropathy in db/db mouse.
8 week old C57BLKS/J db/db mice (type 2 diabetic mouse model) were divided into three groups to feed for 16 weeks on chow diet with or without catalpol supplementation. Their food intake, water consumption, body weight, and fasting glucose levels were recorded every 4 weeks. At the end of study, urine and blood samples were examined for several metabolic variables, and kidneys were harvested for structural characterization and microarray analysis.
Catalpol efficiently lowers the fasting glucose and the 24 h urinary albumin excretion rate. Catalpol significantly lowers serum triglycerides, increases high-density lipoproteins, and improves serum creatinine and urea nitrogen. Catalpol-fed mice preserve their kidney structure and renal function better than chow fed db/db mice. Microarray data indicates that lipid metabolism is a potential target of catalpol in exerting protective effect.
Catalpol has a renal protective effect in diabetic db/db mice.
基金：
This work was supported by the State Administration
of Traditional Chinese Medicine (No.
JDZX2012013), the National Science Foundation
of China (No. 81573812, 81774212),
and the Science & Technical Plan of Guangzhou,
Guangdong, China (No. 2014Y2-00504).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区医学：研究与实验3 区肿瘤学
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区肿瘤学
第一作者：
第一作者机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China
共同第一作者：
通讯作者：
通讯机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China[*1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China.
推荐引用方式(GB/T 7714)：
Pingping Jiang,Lei Xiang,Zewei Chen,et al.Catalpol alleviates renal damage by improving lipid metabolism in diabetic db/db mice.[J].American journal of translational research.2018,10(6):1750-1761.
APA：
Pingping Jiang,Lei Xiang,Zewei Chen,Hanqi Lu,Lin Zhou...&Xiaoshan Zhao.(2018).Catalpol alleviates renal damage by improving lipid metabolism in diabetic db/db mice..American journal of translational research,10,(6)
MLA：
Pingping Jiang,et al."Catalpol alleviates renal damage by improving lipid metabolism in diabetic db/db mice.".American journal of translational research 10..6(2018):1750-1761
