个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

LC-MS/MS-based metabolomic profiling identifies candidate biomarkers in follicular fluid of infertile women with chronic pelvic inflammatory disease

| 认领 | 导出 |

文献详情

资源类型：
Pubmed体系：
作者：
Huang Xuekun[1] * ; Weng Zhiwei[1] ; Zhang Shuting[1] ; Li Xuerong[1] ; Zhou Shaohu[1,*2] ; Liang Jingyao[2,*1] ;
机构： [1]Department of Reproductive Medicine, The First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510095, Guangdong, P. R. China. [2]Department of Dermatology, Guangzhou Institute of Dermatology Guangzhou 510095, Guangdong, P. R. China.
出处：

关键词： Biomarker follicular fluid infertility LC-MS metabolic profiles

摘要：
How chronic pelvic inflammatory disease (CPID), the most common cause of infertility, affects metabolic profiles of follicular fluid (FF) remains unknown. This study aimed to identify candidate biomarkers in FF of infertile women with CPID.FF samples were collected from infertile women with CPID (n = 8) and healthy controls (n = 8) at the time of oocyte retrieval. Untargeted metabolomic profiling of FF samples was conducted using the liquid chromatography-tandem mass spectrometry (LC-MS/MS).A total of 240 differential metabolites (104 named biochemicals and 136 unnamed biochemicals) were screened out and identified. Among them, pregnane-3,3-diol, pc(p-18:1(11z)/18:3(6z,9z,12z)), and 1-octadecanoyl-2-(4z,7z,10z,13z,16z,19z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine were markedly down-regulated, while 17,21-dihydroxypregnenolone was significantly up-regulated in infertile women with CPID. Furthermore, KEGG biological pathway analysis revealed that these metabolites were especially enriched in steroid hormone biosynthesis, glyoxylate and dicarboxylate metabolism, glucagon signaling pathway, and the tricarboxylic acid (TCA) cycle.FF of infertile women with CPID showed unique metabolic changes that may be involved in the pathogenesis of infertility and serve as new therapeutic targets or diagnostic biomarkers.IJCEP Copyright © 2023.

基金：
State Administration of Traditional Chinese Medicine of Guangdong Province (20181097), Youth Research Fund of the First Affiliated Hospital of Guangzhou University of Chinese Medicine (2019QN30), the Research Development Project of Guangzhou University of Chinese Medicine (2021xk64), and the Medical Science and Technology Research Foundation of Guangdong Province (Grant No. A2022052).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
无
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 肿瘤学 4 区 病理学
第一作者：
第一作者机构： [1]Department of Reproductive Medicine, The First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510095, Guangdong, P. R. China.
通讯作者：
通讯机构： [1]Department of Reproductive Medicine, The First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510095, Guangdong, P. R. China. [2]Department of Dermatology, Guangzhou Institute of Dermatology Guangzhou 510095, Guangdong, P. R. China. [*1]Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou 510095, Guangdong, P. R. China. [*2]Department of Reproductive Medicine, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510095, Guangdong, P. R. China
推荐引用方式(GB/T 7714)：
Huang Xuekun,Weng Zhiwei,Zhang Shuting,et al.LC-MS/MS-based metabolomic profiling identifies candidate biomarkers in follicular fluid of infertile women with chronic pelvic inflammatory disease[J].International journal of clinical and experimental pathology.2023,16(2):20-31.
APA：
Huang Xuekun,Weng Zhiwei,Zhang Shuting,Li Xuerong,Zhou Shaohu&Liang Jingyao.(2023).LC-MS/MS-based metabolomic profiling identifies candidate biomarkers in follicular fluid of infertile women with chronic pelvic inflammatory disease.International journal of clinical and experimental pathology,16,(2)
MLA：
Huang Xuekun,et al."LC-MS/MS-based metabolomic profiling identifies candidate biomarkers in follicular fluid of infertile women with chronic pelvic inflammatory disease".International journal of clinical and experimental pathology 16..2(2023):20-31

相关文献

[1]Differential metabolic profiles of ginsenosides in artificial gastric juice using ultra-high-pressure liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry [2]Untargeted serum metabonomics study of psoriasis vulgaris based on ultra-performance liquid chromatography coupled to mass spectrometry [3]LC/MS/MS法同时测定大鼠血浆中芒果苷和小檗碱浓度 [4]LC-MS/MS法测定大鼠知母皂苷B-Ⅱ的血药浓度 [5]基于LC-MS/MS筛选宫颈病变和宫颈癌发生发展过程中的新型蛋白标志物 [6]LC/MS/MS法测定人血浆中秋水仙碱的浓度 [7]LC/MS/MS法测定兔血浆中的盐酸伪麻黄碱及美敏伪麻溶液的药动学研究 [8]LC-MS/MS法测定石斛碱在大鼠体内药代动力学研究 [9]LC/MS/MS测定龙胆苦苷的尿药浓度 [10]LC-MS/MS法测定大鼠血浆中京尼平苷的浓度

资源点击量：2018 今日访问量：0 总访问量：645 更新日期：2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持：重庆聚合科技有限公司 地址：广州市越秀区大德路111号