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Copper-containing chitosan-based hydrogels enabled 3D-printed scaffolds to accelerate bone repair and eliminate MRSA-related infection

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Zhang Jinwei[1,2] * ; Ye Xiangling[3,4,5] * ; Li Wenhua[1] ; Lin Zefeng[2] ; Wang Wanshun[4] ; Chen Lingling[2] ; Li Qi[1] ; Xie Xiaobo[1] ; Xu Xuemeng[4,5,*1] ; Lu Yao[1,2,*2] ;
机构： [1]Departnent of Joint and Orthopedics, Orthopedic Center, Zhujiang Hospitai, Southern Medical University, Guangzhou 510280, China [2]Guangdong Key Lab of Orthopedic Technology and Implant Materials, General Hospital of Southern Theater Command of PLA, Guangzhou 510010, China [3]Department of Orthopedics, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi 330006, China [4]The Fifth Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China [5]Departnent of Orthopedics, Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou, Guangdong 510095, China
出处：
DOI： 10.1016/j.ijbiomac.2023.124463
ISSN：

关键词： Infected bone defect Methicillin-resistant Staphylococcus aureus (MRSA) 3D-printed scaffolds Hydrogels Copper

摘要：
Bone defect combined with drug-resistant bacteria-related infection is a thorny challenge in clinic. Herein, 3D-printed polyhydroxyalkanoates/β-tricalcium phosphate (PHA/β-TCP, PT) scaffolds were prepared by fused deposition modeling. Then copper-containing carboxymethyl chitosan/alginate (CA/Cu) hydrogels were integrated with the scaffolds via a facile and low-cost chemical crosslinking method. The resultant PT/CA/Cu scaffolds could promote not only proliferation but also osteogenic differentiation of preosteoblasts in vitro. Moreover, PT/CA/Cu scaffolds exhibited a strong antibacterial activity towards a broad-spectrum of bacteria including methicillin-resistant Staphylococcus aureus (MRSA) through inducing the intercellular generation of reactive oxygen species. In vivo experiments further demonstrated that PT/CA/Cu scaffolds significantly accelerated bone repair of cranial defects and efficiently eliminated MRSA-related infection, showing potential for application in infected bone defect therapy.Copyright © 2023. Published by Elsevier B.V.

基金：
This work was financially supported by National Natural Science Foundation of China (81972080), the Science and Technology Planning Project of Guangzhou (2021 02080527), Natural Science Foundation of Guangdong Province (2022A1515010307, 2021A1515011545), Natural Science Foundation of Jiangxi Province of China (20224BAB21 6094), and President Foundation of Zhujiang Hospital, Southern Medical Uni- versity (yzjj2018rc09). .
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 化学
小类 | 1 区 高分子科学 2 区 应用化学 2 区 生化与分子生物学
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 应用化学 2 区 高分子科学
JCR分区：
出版当年[2021]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CHEMISTRY, APPLIED Q1 POLYMER SCIENCE
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CHEMISTRY, APPLIED Q1 POLYMER SCIENCE

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Departnent of Joint and Orthopedics, Orthopedic Center, Zhujiang Hospitai, Southern Medical University, Guangzhou 510280, China [2]Guangdong Key Lab of Orthopedic Technology and Implant Materials, General Hospital of Southern Theater Command of PLA, Guangzhou 510010, China
共同第一作者：
通讯作者：
通讯机构： [1]Departnent of Joint and Orthopedics, Orthopedic Center, Zhujiang Hospitai, Southern Medical University, Guangzhou 510280, China [2]Guangdong Key Lab of Orthopedic Technology and Implant Materials, General Hospital of Southern Theater Command of PLA, Guangzhou 510010, China [4]The Fifth Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China [5]Departnent of Orthopedics, Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou, Guangdong 510095, China [*1]Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China. [*2]Department of Joint and Orthopedics, Orthopedic Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
推荐引用方式(GB/T 7714)：
Zhang Jinwei,Ye Xiangling,Li Wenhua,et al.Copper-containing chitosan-based hydrogels enabled 3D-printed scaffolds to accelerate bone repair and eliminate MRSA-related infection[J].INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2023,240:doi:10.1016/j.ijbiomac.2023.124463.
APA：
Zhang Jinwei,Ye Xiangling,Li Wenhua,Lin Zefeng,Wang Wanshun...&Lu Yao.(2023).Copper-containing chitosan-based hydrogels enabled 3D-printed scaffolds to accelerate bone repair and eliminate MRSA-related infection.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,240,
MLA：
Zhang Jinwei,et al."Copper-containing chitosan-based hydrogels enabled 3D-printed scaffolds to accelerate bone repair and eliminate MRSA-related infection".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 240.(2023)

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