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Membranous nephropathy: Mechanistic insights and therapeutic perspectives

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机构： [1]Xi’an International Medical Center Hospital, Northwest University, No. 777 Xitai Road, Xi’an, Shaanxi 710000, China [2]Guangdong nephrotic drug Engineering Technology Research Center, Institute of Consun Co. for Chinese Medicine in Kidney Diseases, Guangdong Consun Pharmaceutical Group, No. 71 Dongpeng avenue, Guangzhou, Guangdong 510530, China [3]School of Food and Bioengineering, Chengdu University, No. 2025 Chengluo Avenue, Chengdu, Sichuan 610106, China [4]School of Pharmacy, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou, Zhejiang 310053, China

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关键词： Primary membranous nephropathy Immune pathogenesis Anti-PLA2R antibody Anti-THSD7A antibody Immunosuppressive therapy

摘要：

Membranous nephropathy (MN) is one of the most common causes of non-diabetic nephrotic syndrome in adults. About 80% of cases are renal limited (primary MN) and 20% are associated with other systemic diseases or exposures (secondary MN). Autoimmune reaction is the main pathogenic factor of MN, and the discovery of autoantigens including the phospholipase A2 receptor and thrombospondin type-1 domain-containing protein 7A has led to new insights into the pathogenesis, they can induce humoral immune responses led by IgG4 makes them suitable for the diagnosis and monitoring of MN. In addition, complement activation, genetic susceptibility genes and environmental pollution are also involved in MN immune response. In clinical practice, due to the spontaneous remission of MN, the combination of supportive therapy and pharmacological treatment is widely used. Immunosuppressive drugs are the cornerstone of MN treatment, and the dangers and benefits of this approach vary from person to person. In summary, this review provides a more comprehensive review of the immune pathogenesis, interventions and unresolved issues of MN in the hope of providing some new ideas for clinical and scientific researchers in the treatment of MN.Copyright © 2023 Elsevier B.V. All rights reserved.

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出版当年[2022]版：

大类 | 2 区医学

小类 | 2 区免疫学 2 区药学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区药学 3 区免疫学

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第一作者机构： [1]Xi’an International Medical Center Hospital, Northwest University, No. 777 Xitai Road, Xi’an, Shaanxi 710000, China

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通讯机构： [1]Xi’an International Medical Center Hospital, Northwest University, No. 777 Xitai Road, Xi’an, Shaanxi 710000, China [3]School of Food and Bioengineering, Chengdu University, No. 2025 Chengluo Avenue, Chengdu, Sichuan 610106, China [4]School of Pharmacy, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou, Zhejiang 310053, China [*1]School of Pharmacy, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou, Zhejiang 310053, China [*2]Xi’an International Medical Center Hospital, Northwest University, No. 777 Xitai Road, Xi’an, Shaanxi 710000, China

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