个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

Sirtuin4 impacts mitochondrial homeostasis in pancreatic cancer cells by reducing the stability of AlkB homolog 1 via deacetylation of the HRD1-SEL1L complex

| 认领 | 导出 | |

文献详情

资源类型：
Pubmed体系：
作者：
Ping Dongnan[1] * ; Pu Xiaofan[1] * ; Ding Guoping[1] ; Zhang Chaolei[1] ; Jin Junbin[1] ; Xu Chengjie[1] ; Liu Jiazheng[2] ; Jia Shengnan[1,3,*1] ; Cao Liping[1,3,*1] ;
机构： [1]Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3, Qingchun Road, Hangzhou, China [2]State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease, Macau University of Science and Technology, Taipa, Macao [3]Zhejiang Engineering Research Center of Cognitive Healthcare, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China
出处：
DOI： 10.1016/j.bbagrm.2023.194941
ISSN：

关键词： SIRT4 ALKBH1 HRD1-SEL1L Mitochondrial function Pancreatic cancer

摘要：
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with a poor prognosis. As a tumor inhibitor, the specific tumor suppressor mechanism of Sirtuin4(SIRT4) in PDAC remains elusive. In this study, SIRT4 was found to inhibit PDAC by impacting mitochondrial homeostasis. SIRT4 deacetylated lysine 547 of SEL1L and increased the protein level of an E3 ubiquitin ligase HRD1. As a central member of ER-associated protein degradation (ERAD), HRD1-SEL1L complex is recently reported to regulate the mitochondria, though the mechanism is not fully delineated. Here, we found the increase in SEL1L-HRD1 complex decreased the stability of a mitochondrial protein, ALKBH1. Downregulation of ALKBH1 subsequently blocked the transcription of mitochondrial DNA-coded genes, and resulted in mitochondrial damage. Lastly, a putative SIRT4 stimulator, Entinostat, was identified, which upregulated the expression of SIRT4 and effectively inhibited pancreatic cancer in vivo and in vitro.Copyright © 2023. Published by Elsevier B.V.

基金：
Funding for this work was provided by the Natural Science Foundation of China (81971479 to Liping Cao), Basic Public Welfare Research Program of Zhejiang Province (LGD22H160007 to Shengnan Jia), Basic Public Welfare Research Program of Zhejiang Province (LGF21H160026 to Guoping Ding).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 生物学
小类 | 2 区 生物物理 3 区 生化与分子生物学
最新[2025]版：
大类 | 3 区 生物学
小类 | 3 区 生物物理 4 区 生化与分子生物学
第一作者：
第一作者机构： [1]Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3, Qingchun Road, Hangzhou, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3, Qingchun Road, Hangzhou, China [3]Zhejiang Engineering Research Center of Cognitive Healthcare, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China [*1]Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3, Qingchun Road, Hangzhou, China.
推荐引用方式(GB/T 7714)：
Ping Dongnan,Pu Xiaofan,Ding Guoping,et al.Sirtuin4 impacts mitochondrial homeostasis in pancreatic cancer cells by reducing the stability of AlkB homolog 1 via deacetylation of the HRD1-SEL1L complex[J].Biochimica et biophysica acta. Gene regulatory mechanisms.2023,1866(2):194941.doi:10.1016/j.bbagrm.2023.194941.
APA：
Ping Dongnan,Pu Xiaofan,Ding Guoping,Zhang Chaolei,Jin Junbin...&Cao Liping.(2023).Sirtuin4 impacts mitochondrial homeostasis in pancreatic cancer cells by reducing the stability of AlkB homolog 1 via deacetylation of the HRD1-SEL1L complex.Biochimica et biophysica acta. Gene regulatory mechanisms,1866,(2)
MLA：
Ping Dongnan,et al."Sirtuin4 impacts mitochondrial homeostasis in pancreatic cancer cells by reducing the stability of AlkB homolog 1 via deacetylation of the HRD1-SEL1L complex".Biochimica et biophysica acta. Gene regulatory mechanisms 1866..2(2023):194941

相关文献

[1]中医治疗胰腺癌思路与方法探讨 [2]Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression. [3]Multimodal Imaging-Guided Photoimmunotherapy of Pancreatic Cancer by Organosilica Nanomedicine [4]Sinisan alleviates depression-like behaviors by regulating mitochondrial function and synaptic plasticity in maternal separation rats [5]Electroacupuncture alleviates multifidus muscle injury by modulating mitochondrial function and Ca2+ uptake. [6]Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism. [7]ATP synthase inhibitory factor subunit 1 regulates islet β-cell function via repression of mitochondrial homeostasis. [8]Artemether improves type 1 diabetic kidney disease by regulating mitochondrial function. [9]LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9 [10]Proteomics Revealed That Mitochondrial Function Contributed to the Protective Effect of Herba Siegesbeckiae Against Cardiac Ischemia/Reperfusion Injury

资源点击量：2018 今日访问量：0 总访问量：645 更新日期：2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持：重庆聚合科技有限公司 地址：广州市越秀区大德路111号