机构：[1]The Third Department of Oncology, The First Affiliated Hospital of Hunan College of Traditional Chinese Medicine, Zhuzhou, Hunan[2]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong[3]Department of Traditional Chinese Medicine, The First Affiliated Hospital of Xian Jiaotong University, Xian, Shanxi, People’s Republic of China
Paeoniflorin (PF) is an active monoterpene glycoside extracted from Paeonia lactiflora Pall. PF has exhibited antitumor effects in various cancer types. However, the effects of PF in pancreatic cancer are largely unexplored. Here, we showed that PF suppressed growth of pancreatic cancer cell lines Capan-1 and MIAPaCa-2 and profoundly sensitized these cells to X-ray irradiation. Through microarray analysis, we identified HTRA3, a tumor-suppressor candidate gene, as the most increased gene upon PF treatment in Capan-1 cells. Ectopic expression of HTRA3 led to reduced cell proliferation and increased expression of apoptotic protein Bax, suggesting a tumor suppressive role of HTRA3 in pancreatic cancer cells. Together, our results provide a set group of genetic proofs and biological proofs that PF inhibited pancreatic cancer growth by upregulating HTRA3.
基金：
This work was supported by the Hunan Administration Traditional Chinese Medicine Foundation (201737) and the National Science Foundation of China (81500738).
第一作者机构：[1]The Third Department of Oncology, The First Affiliated Hospital of Hunan College of Traditional Chinese Medicine, Zhuzhou, Hunan
共同第一作者：
通讯作者：
通讯机构：[1]The Third Department of Oncology, The First Affiliated Hospital of Hunan College of Traditional Chinese Medicine, Zhuzhou, Hunan[*1]The First Affiliated Hospital of Hunan College of Traditional Chinese Medicine, 571 Middle People Road, Zhuzhou, Hunan, 412000, People’s Republic of China
推荐引用方式(GB/T 7714)：
Yuejun Li,Lili Gong,Ruili Qi,et al.Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression.[J].DRUG DESIGN DEVELOPMENT AND THERAPY.2017,11:2481-2491.doi:10.2147/DDDT.S134518.
APA：
Yuejun Li,Lili Gong,Ruili Qi,Qian Sun,Xinxin Xia...&Debin Zhuo.(2017).Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression..DRUG DESIGN DEVELOPMENT AND THERAPY,11,
MLA：
Yuejun Li,et al."Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression.".DRUG DESIGN DEVELOPMENT AND THERAPY 11.(2017):2481-2491
