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Tiliroside induces ferroptosis to repress the development of triple-negative breast cancer cells

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机构： [1]Department of Thoracic Surgery, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China [2]Department of Oncology, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China [3]Cancer center, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518000, China [4]Department of Radiation Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China

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关键词： Tiliroside Triple-negative breast cancer Ferroptosis HO-1

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Ferroptosis is a newly found form of non-apoptotic regulated cell death that is essential for the advancement of cancer. Tiliroside (Til), an effective natural flavonoid glycoside of oriental paperbush flower, has been explored as a potential anticancer agent in a few cancer types. However, it is unclear whether and how Til could promote the death of triple-negative breast cancer (TNBC) cells by inducing ferroptosis. Our study determined that Til induced cell death and attenuated cell proliferation in TNBC cells in vitro and in vivo with less toxicity for the first time. Functional assays showed that ferroptosis was the predominant form that contributed to Til-induced cell death of TNBC. Mechanistically, Til induces ferroptosis of TNBC cells via independent PUFA-PLS pathways but is closely involved in the Nrf2/HO-1 pathway. Silencing of HO-1 substantially abrogated the tumor-inhibiting effects of Til. In conclusion, our findings suggest that the natural product Til exerted its antitumor activity on TNBC by promoting ferroptosis, and the HO-1/SLC7A11 pathway plays an indispensable role in Til-induced ferroptotic cell death.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

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出版当年[2022]版：

大类 | 4 区生物学

小类 | 4 区解剖学与形态学 4 区细胞生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区解剖学与形态学 4 区细胞生物学

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出版当年[2021]版：

Q2 ANATOMY & MORPHOLOGY Q4 CELL BIOLOGY

最新[2023]版：

Q1 ANATOMY & MORPHOLOGY Q3 CELL BIOLOGY

影响因子： 2.7 最新[2023版] 2.5 最新五年平均 2.586 出版当年[2021版] 2.331 出版当年五年平均 2.466 出版前一年[2020版] 2.6 出版后一年[2022版]

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第一作者机构： [1]Department of Thoracic Surgery, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China

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