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A novel axis of circKIF4A-miR-637-STAT3 promotes brain metastasis in triple-negative breast cancer

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收录情况： ◇ SCIE

作者：
Wu Song[1] * ; Lu Jibu[1] * ; Zhu Hongbo[2] ; Wu Feiyue[3] ; Mo Yunxian[1] ; Xie Liming[2] ; Song Cailu[1] ; Liu Lingrui[1] ; Xie Xiaoming[1] ; Li Yuehua[2] ; Lin Huan[4] ; Tang Hailin[1] ;
机构： [1]State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, China [2]The First Affiliated Hospital of Hengyang Medical School, University of South China, Hengyang, China [3]Guizhou Provincial People’s Hospital, Guiyang, China [4]The Affiliated TCM Hospital of Guangzhou Medical University, Guangzhou, China
出处：
DOI： 10.1016/j.canlet.2023.216508
ISSN：

关键词： Triple-negative breast cancer circKIF4A Circular RNAs Autophagy Competitive endogenous RNAs

摘要：
Among patients with triple-negative breast cancer (TNBC), distant metastasis is the leading cause of death. Our previous studies have shown that TNBC progression is greatly facilitated by circKIF4A, but uncertainty remains regarding its role in TNBC brain metastasis and the molecular mechanism. In this study, we found notable upregulation of circKIF4A in TNBC cell lines and brain metastases. Inhibition of circKIF4A impaired the ability of TNBC to proliferate, migrate, and cause brain metastasis. Luciferase reporter assays confirmed that circKIF4A competed for binding to miR-637 with STAT3 3' UTR. Western blot analysis revealed that inhibition of circKIF4A decreased STAT3 and p62 expression, while increased the LC3B-II/LC3B-I ratio and the expression of Beclin, indicating that downregulation of circKIF4A induced autophagy by competing with STAT3 for binding to miR-637. By employing a competitive endogenous RNA (ceRNA) mechanism, the circKIF4A-miR-637-STAT3 axis coordinates brain metastasis in TNBC. circKIF4A can therefore be used as a prognostic biomarker for brain metastasis in TNBC and as a therapeutic target.Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

基金：
This study was supported by the National Natural Science Foundation of China (82273399, Hailin Tang), the Medicine Foundation of Wu Jieping (32067502022-3-58, Huan Lin), the Natural Science Foundation of Guangdong (2022A1515012213, Yunxian Mo), the Natural Science Foundation of Hunan Province (2023JJ60496, Yuehua Li), Clinical Medical Research 4310 Program of the University of South China (20224310NHYCG07, Yuehua Li) and the Science and Technology Foundation of Hunan Province (2021SK51818, Liming Xie).
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外文
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出版当年[2023]版：
大类 | 1 区 医学
小类 | 2 区 肿瘤学
最新[2025]版：
大类 | 1 区 医学
小类 | 2 区 肿瘤学
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出版当年[2022]版：
Q1 ONCOLOGY
最新[2023]版：
Q1 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, China
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推荐引用方式(GB/T 7714)：
Wu Song,Lu Jibu,Zhu Hongbo,et al.A novel axis of circKIF4A-miR-637-STAT3 promotes brain metastasis in triple-negative breast cancer[J].CANCER LETTERS.2024,581:doi:10.1016/j.canlet.2023.216508.
APA：
Wu Song,Lu Jibu,Zhu Hongbo,Wu Feiyue,Mo Yunxian...&Tang Hailin.(2024).A novel axis of circKIF4A-miR-637-STAT3 promotes brain metastasis in triple-negative breast cancer.CANCER LETTERS,581,
MLA：
Wu Song,et al."A novel axis of circKIF4A-miR-637-STAT3 promotes brain metastasis in triple-negative breast cancer".CANCER LETTERS 581.(2024)

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