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Nanowired Delivery of Curcumin Attenuates Methamphetamine Neurotoxicity and Elevates Levels of Dopamine and Brain-Derived Neurotrophic Factor

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Pubmed体系：
作者：
Ottonelli Ilaria[1] * ; Sharma Aruna[2] ; Ruozi Barbara[1] ; Tosi Giovanni[1] ; Duskey Jason Thomas[1] ; Vandelli Maria Angela[1] ; Lafuente José Vicente[3] ; Nozari Ala[4] ; Muresanu Dafin Fior[5,6] ; Buzoianu Anca Dana[7] ; Tian Z Ryan[8] ; Zhang Zhiqiang[9] ; Li Cong[9] ; Feng Lianyuan[10] ; Wiklund Lars[2] ; Sharma Hari Shanker[2] ;
机构： [1]Te.far.t.I, Dept of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy. [2]International Experimental Central Nervous System Injury & Repair (IECNSIR), Surgical Sciences, Anesthesiology & Intensive Care Med., Uppsala University Hospital, Uppsala University, Uppsala, Sweden. [3]LaNCE, Department Neuroscience, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain. [4]Anesthesia and Critical Care, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA. [5]"RoNeuro" Institute for Neurological Research and Diagnosis, Cluj-Napoca, Romania. [6]Clinical Neurosciences, University of Medicine & Pharmacy, Cluj-Napoca, Romania. [7]Department of Clinical Pharmacology and Toxicology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. [8]Dept. Chemistry & Biochemistry, University of Arkansas, Fayetteville, AR, USA. [9]Department of Neurosurgery, Chinese Medicine Hospital of Guangdong Province. The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China. [10]Department of Neurology, Bethune International Peace Hospital, Zhongshan Road (West), Shijiazhuang, Hebei Province, China.
出处：
DOI： 10.1007/978-3-031-32997-5_10
ISSN：

关键词： Curcumin Nanodelivery Methamphetamine Neurotoxicity Blood– brain barrier Brain edema Brain-derived neurotrophic factor Dopamine Neuroprotection

摘要：
Curcumin is a well-known antioxidant used as traditional medicine in China and India since ages to treat variety of inflammatory ailments as a food supplement. Curcumin has antitumor properties with neuroprotective effects in Alzheimer's disease. Curcumin elevates brain-derived neurotrophic factor (BDNF) and dopamine (DA) levels in the brain indicating its role in substance abuse. Methamphetamine (METH) is one of the most abused substances in the world that induces profound neurotoxicity by inducing breakdown of the blood-brain barrier (BBB), vasogenic edema and cellular injuries. However, influence of curcumin on METH-induced neurotoxicity is still not well investigated. In this investigation, METH neurotoxicity and neuroprotective effects of curcumin nanodelivery were examined in a rat model. METH (20 mg/kg, i.p.) neurotoxicity is evident 4 h after its administration exhibiting breakdown of BBB to Evans blue albumin in the cerebral cortex, hippocampus, cerebellum, thalamus and hypothalamus associated with vasogenic brain edema as seen measured using water content in all these regions. Nissl attaining exhibited profound neuronal injuries in the regions of BBB damage. Normal curcumin (50 mg/kg, i.v.) 30 min after METH administration was able to reduce BBB breakdown and brain edema partially in some of the above brain regions. However, TiO2 nanowired delivery of curcumin (25 mg/kg, i.v.) significantly attenuated brain edema, neuronal injuries and the BBB leakage in all the brain areas. BDNF level showed a significant higher level in METH-treated rats as compared to saline-treated METH group. Significantly enhanced DA levels in METH-treated rats were also observed with nanowired delivery of curcumin. Normal curcumin was able to slightly elevate DA and BDNF levels in the selected brain regions. Taken together, our observations are the first to show that nanodelivery of curcumin induces superior neuroprotection in METH neurotoxicity probable by enhancing BDNF and DA levels in the brain, not reported earlier.© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.

基金：
Ministry of Science & Technology, People Republic of China, the Air Force Office of Scientific Research (EOARD, London, UK), and Air Force Material Command, USAF, under grant number FA8655-05-1-3065; Grants from the Alzheimer’s Association (IIRG-09- 132087), the National Institutes of Health (R01 AG028679) and the Dr. Robert M. Kohrman Memorial Fund (RJC); Swedish Medical Research Council (Nr 2710-HSS), Göran Gustafsson Foundation, Stockholm, Sweden (HSS), Astra Zeneca, Mölndal, Sweden (HSS/AS), The University Grants Commission, New Delhi, India (HSS/AS), Ministry of Science & Technology, Govt. of India (HSS/AS), Indian Medical Research Council, New Delhi, India (HSS/AS) and India-EU Co-operation Program (AS/HSS) and IT-901/16 (JVL), Government of Basque Country and PPG 17/51 (JVL), JVL thanks to the support of the University of the Basque Country (UPV/EHU) PPG 17/51 and 14/08, the Basque Government (IT-901/16 and CS-2203) Basque Country, Spain; and Foundation for Nanoneuroscience and Nanoneuroprotection (FSNN), Romania. Technical and human support provided by Dr. Ricardo Andrade from SGIker (UPV/EHU) is gratefully acknowledged.
语种：
外文
PubmedID：
第一作者：
第一作者机构： [1]Te.far.t.I, Dept of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
通讯作者：
推荐引用方式(GB/T 7714)：
Ottonelli Ilaria,Sharma Aruna,Ruozi Barbara,et al.Nanowired Delivery of Curcumin Attenuates Methamphetamine Neurotoxicity and Elevates Levels of Dopamine and Brain-Derived Neurotrophic Factor[J].Advances in neurobiology.2023,32:385-416.doi:10.1007/978-3-031-32997-5_10.
APA：
Ottonelli Ilaria,Sharma Aruna,Ruozi Barbara,Tosi Giovanni,Duskey Jason Thomas...&Sharma Hari Shanker.(2023).Nanowired Delivery of Curcumin Attenuates Methamphetamine Neurotoxicity and Elevates Levels of Dopamine and Brain-Derived Neurotrophic Factor.Advances in neurobiology,32,
MLA：
Ottonelli Ilaria,et al."Nanowired Delivery of Curcumin Attenuates Methamphetamine Neurotoxicity and Elevates Levels of Dopamine and Brain-Derived Neurotrophic Factor".Advances in neurobiology 32.(2023):385-416

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