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Bio-based Carbon dots Loaded with 5-Fu: A Multifunctional drug Delivery System

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机构： [1]School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China [2]Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou 510006, China [3]Guangdong Dongshenglin Pharmaceutical Co., Ltd, Guangzhou 510006, China [4]Yunfu Traditional Chinese Medicine Hospital, Yunfu 527300, China

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关键词： Carbon dots Fu Drug release Anticancer Cell imaging

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In the present work, a simple and efficient stirring method was used to successfully synthesize a novel multifunctional carbon dots-drug delivery system AMP-CDs@5-Fu in the form of intertwined filaments. The results showed that AMP-CDs@5-Fu had the highest final release in the medium mimicking the physiological environment of the human small intestine compared to that of 5-Fu and that the drug release behaviors followed a zero-grade drug release within the first 3 h. The results also showed that AMP-CDs@5-Fu could be used to reduce the toxicity of 5-Fu while significantly improving the anticancer ability. In vitro hemolysis and anticancer assays showed that AMP-CDs@5-Fu could significantly improve the anticancer ability while decreasing the toxicity of 5-Fu, and the hemolysis rate of AMP-CDs@5-Fu was significantly lower than that of 5-Fu; their IC50 against 4T1 cancer cells were 201.63 ± 8.94 µg 5-Fu/mL and 241.24 ± 11.05 µg 5- Fu/mL. In addition, AMP-CDs@5-Fu allowed clear cell imaging. Therefore, AMP-CDs@5-Fu is expected to improve the bioavailability of 5-Fu as a novel oral agent with fluorescent properties and very promising as a novel fluorescence tracking drug loading system, which is expected to be used in the field of anticancer targeted therapy and fluorescence tracking to monitor the distribution of drugs.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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出版当年[2022]版：

大类 | 4 区化学

小类 | 4 区分析化学 4 区物理化学 4 区生化研究方法

最新[2025]版：

大类 | 3 区化学

小类 | 4 区生化研究方法 4 区分析化学 4 区物理化学

第一作者：

第一作者机构： [1]School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China

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通讯机构： [1]School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China [2]Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou 510006, China [3]Guangdong Dongshenglin Pharmaceutical Co., Ltd, Guangzhou 510006, China

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