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Acupuncture mitigates chronic unpredictable mild stress-induced depression-like behaviours via Lateral Habenula and Gut-Liver-Brain Axis

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资源类型：
Pubmed体系：
作者：
Chen Wenjie[1] * ; Chen Yiping[2] * ; Aslam Muhammad Shahzad[3] ; Shen Junliang[1] ; Tong Tao[2] ; Yan Simin[1] ; Cheng Wenjing[4] ; Huang Zichun[1] ; Li Jiawei[1] ; Liu Siyu[5] ; Li Jianguo[2] ; Meng Xianjun[1,6] ;
机构： [1]Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, P. R. China [2]Second Clinical College, Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, P. R. China [3]School of Traditional Chinese Medicine, Xiamen University Malaysia, Sepang, Malaysia [4]Department of Rehabilitation Medicine, Ezhou Central Hospital, Ezhou, Hubei, P. R. China [5]Department of Acupuncture, Longyan Hospital of Traditional Chinese Medicine, Longyan, Fujian, P. R. China [6]Shenzhen Research Institute of Xiamen University, Shenzhen, Guangdong, P. R. China
出处：
DOI： 10.1016/j.bbr.2023.114627
ISSN：

关键词： acupuncture depression Inflammation lateral habenula Gut-liver-brain axis Nitric oxide/cyclic-guanosine monophosphate pathway

摘要：
Depression is a severe emotional condition that significantly affects the quality of life. Acupuncture exerts preventive effects on depression in rats with post-chronic unpredictable mild stress (CUMS). Methods The study involved chronic unpredictable mild stress (CUMS) depression model mice to administer acupuncture as a preventative measure to investigate the mechanism of acupuncture's antidepressant and observe the effect of acupuncture on impact via the Lateral Habenula (LHb) and Gut-Liver-Brain Axis. The researcher investigated molecules correlating with a nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway and assessed inflammation in the LHb and liver. In addition, 16S rDNA bioinformatics study revealed the quantity and variety of gut microbiota. Rats were randomly divided into five groups: control (CON), CUMS, CUMS + acupuncture (AP), CUMS + fluoxetine (FX) and CUMS + N(G) -nitro -L- arginine methyl ester (LNAME) group. Except for the CON group, other rats were exposed to CUMS condition for 28 days. Simultaneously, manual acupuncture (at Fengfu and Shangxing acupoints, once every other day) and fluoxetine gavage (2.1mg/kg, 0.21mg/mL, daily) were conducted to the groups of AP and FX, respectively, after stressors. Rats in LNAME group were treated with LNAME normal saline (10mg/kg, 1mg/mL, i.p.) solution. Behavioural tests and biological detection methods were conducted sequentially to evaluate depressionlike phenotype in rats.The results showed CUMS induced depression-like behaviours, hyper-activation of NO/cGMP signaling pathway, inflammation in serum, LHb and liver, and dysbiosis of the gut microbiota. These changes could be prevented and ameliorated by acupuncture to varying extents.Acupuncture prevented and attenuated depression-like phenotype induced by CUMS, possibly via regulating the NO/cGMP signaling pathway and thus improving inflammation in serum, LHb and liver, and gut microbiota dysbiosis. In addition, these can be evidence of the existence of the gut-liver-brain axis.Copyright © 2023. Published by Elsevier B.V.

语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 心理学
小类 | 3 区 行为科学 3 区 神经科学
最新[2025]版：
大类 | 3 区 心理学
小类 | 3 区 行为科学 4 区 神经科学
第一作者：
第一作者机构： [1]Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, P. R. China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, P. R. China [6]Shenzhen Research Institute of Xiamen University, Shenzhen, Guangdong, P. R. China
推荐引用方式(GB/T 7714)：
Chen Wenjie,Chen Yiping,Aslam Muhammad Shahzad,et al.Acupuncture mitigates chronic unpredictable mild stress-induced depression-like behaviours via Lateral Habenula and Gut-Liver-Brain Axis[J].Behavioural brain research.2023,114627.doi:10.1016/j.bbr.2023.114627.
APA：
Chen Wenjie,Chen Yiping,Aslam Muhammad Shahzad,Shen Junliang,Tong Tao...&Meng Xianjun.(2023).Acupuncture mitigates chronic unpredictable mild stress-induced depression-like behaviours via Lateral Habenula and Gut-Liver-Brain Axis.Behavioural brain research,,
MLA：
Chen Wenjie,et al."Acupuncture mitigates chronic unpredictable mild stress-induced depression-like behaviours via Lateral Habenula and Gut-Liver-Brain Axis".Behavioural brain research .(2023):114627

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