机构：[1]Department of Acupuncture and Moxibustion, Guangdong Provincial Hospital of TCM, Guangzhou, China大德路总院针灸科大德路总院针灸科广东省中医院[2]Post-doctoral Research Station of Guangzhou University of Chinese Medicine, Guangzhou, China[3]Division of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ[4]Guangzhou University of Chinese Medicine, Guangzhou, China深圳市中医院深圳医学信息中心[5]School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong[6]Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Guangxi University of ChineseMedicine, Nanning, China[7]Primary Registry of WHO ICTRP, Chinese Clinical Trial Registry, Chinese Evidence-Based Medicine Center, Chinese Cochrane Center, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院[8]Epidemiology Center, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China广东省中医院
Background: Acupuncture is an ancient medical technique of China. Clinical studies have found that acupuncture is an effective treatment modality for remitting stress disorder, anxiety, and depression. Objective: This study investigated the molecular mechanisms of acupuncture that have been demonstrated to be beneficial for treating depression. Methods: A depressive disorder model was induced by exposing Sprague Dawley rats to chronic unpredictable stress. Acupuncture stimulation and riluzole were used to treat the depressed rats. Physical and pathologic changes-including behavioral performance, body weight, hippocampal glutamate concentration, and glutamate-glutamine cycle related genes-were analyzed before and after therapy. Results: Acupuncture improved behavioral performance, reduced glutamate in the hippocampus, prevented damage to hippocampal neurons, reduced glutamate release, and increased glutamate recycling. Conclusions: Acupuncture is a safe and effective modality for depression therapy in rats. Acupuncture treatments may relieve depression and reduce glutamate content to normal levels. Additional research is needed to assess the effect of acupuncture on depression in human patients and to explore other possible mechanisms.
第一作者机构：[1]Department of Acupuncture and Moxibustion, Guangdong Provincial Hospital of TCM, Guangzhou, China[2]Post-doctoral Research Station of Guangzhou University of Chinese Medicine, Guangzhou, China
通讯作者：
通讯机构：[1]Department of Acupuncture and Moxibustion, Guangdong Provincial Hospital of TCM, Guangzhou, China[*1]Department of Acupuncture and Moxibustion Guangdong Provincial Hospital of Traditional Chinese Medicine No. 111 Dade Road Guangzhou 510120 China
推荐引用方式(GB/T 7714)：
Fan Ling,Chen Zhao,Fu Wenbin,et al.Glutamate of Hippocampus Involved in Remission of Depression by Acupuncture in Rats[J].MEDICAL ACUPUNCTURE.2016,28(2):71-78.doi:10.1089/acu.2016.1174.
APA：
Fan, Ling,Chen, Zhao,Fu, Wenbin,Xu, Nenggui,Liu, Jianhua...&Ou, Aihua.(2016).Glutamate of Hippocampus Involved in Remission of Depression by Acupuncture in Rats.MEDICAL ACUPUNCTURE,28,(2)
MLA：
Fan, Ling,et al."Glutamate of Hippocampus Involved in Remission of Depression by Acupuncture in Rats".MEDICAL ACUPUNCTURE 28..2(2016):71-78
