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Aberrant expression of PELI1 caused by Jagged1 accelerates the malignant phenotype of pancreatic cancer

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收录情况： ◇ SCIE

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机构： [1]Department of Pathology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China. [2]Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China. [3]Department of Gastroenterology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.

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关键词： PELI1 Jagged1 Pancreatic cancer Apoptosis Cell proliferation

摘要：

Pancreatic cancer is one of the most aggressive cancers. PELI1 has been reported to promote cell survival and proliferation in multiple cancers. As of now, the role of PELI1 in pancreatic cancer is largely unknown. Here, we found that the PELI1 mRNA was higher expressed in pancreatic tumor tissues than in adjacent normal tissues, and the high PELI1 level in pancreatic cancer patients had a short survival time compared with the low level. Moreover, the results showed that PELI1 promoted cell proliferation, migration, and invasion, and inhibited apoptosis in vitro. Xenograft tumor experiments were used to determine the biological function of PELI1, and the results showed that PELI1 promoted tumor growth in vivo. Additionally, we found that Jagged1 activated PELI1 transcription in pancreatic cancer cells. To sum up, our results show that PELI1 affects the malignant phenotype of pancreatic cancer.Copyright © 2023 Elsevier Inc. All rights reserved.

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出版当年[2022]版：

大类 | 2 区生物学

小类 | 3 区细胞生物学

最新[2025]版：

大类 | 2 区生物学

小类 | 3 区细胞生物学

JCR分区：

出版当年[2021]版：

Q2 CELL BIOLOGY

最新[2023]版：

Q2 CELL BIOLOGY

影响因子： 4.4 最新[2023版] 4.4 最新五年平均 4.85 出版当年[2021版] 4.633 出版当年五年平均 4.315 出版前一年[2020版] 4.8 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Pathology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.

通讯作者：

通讯机构： [2]Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China. [3]Department of Gastroenterology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China. [*1]Department of General Surgery, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, Liaoning Province, China. [*2]Department of Gastroenterology, The Fourth Affiliated Hospital of China Medical University, No. 4, Chongshan East Road, Huanggu District, Shenyang, Liaoning Province, China.

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