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Effect of polysaccharide from Undaria pinnatifida on proliferation, migration and apoptosis of breast cancer cell MCF7.

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收录情况： ◇ SCIE

作者：
Wu Jun[a,d] * ; Li Hailun[b] * ; Wang Xinyue[c] * ; Zhang Xiaolei[f] ; Liu Weiping[a] ; Wang Yumei[a] ; Zhang Yongbin[a] ; Pan Huafeng[a] ; Wang Qi[a] ; Han Yun[e] ;
机构： [a]Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [b]Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an 223001, Jiangsu, PR China [c]Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong, PR China [d]School of Chinese Medicine, Shandong College of Traditional Chinese Medicine, Yantai 264199, Shangdong, PR China [e]School of Integrated Chinese and Western Medicine, Binzhou Medical University, Yantai 264003, Shangdong, PR China [f]Jiangsu Vocational College of Nursing, Huai'an 223003, Jiangsu, China
出处：
DOI： 10.1016/j.ijbiomac.2018.10.086
ISSN：

关键词： Polysaccharide Undaria pinnatifida Anti-breast cancer

摘要：
Sulfated polysaccharide from Undaria pinnatifida (SPUP) has significant anti-breast cancer activity. However, its anticarcinogenic mechanism still remains unclear. The aim of this article is to observe the effect of SPUP on proliferation, migration and apoptosis of human breast cancer cell line MCF7. Firstly, the effect of SPUP on proliferation was evaluated through MTT assay, plate clonality assay and immunofluorescence test of PCNA. The results showed that SPUP could significantly reduce MCF7 cells proliferation in a time- and dose-dependent manner. Based on transwell and scratch wound healing assays, then, inhibitory action of SPUP for MCF7 cells migration was observed. Finally, apoptosis and cycle arrest of SPUP for MCF7 cells also were found by the results from both flow cytometry analysis and Hoechst 33342 staining of apoptotic cells. Overall, these results showed anti-breast cancer mechanism of SPUP could be possibly related to inhibit migration, proliferation and induce apoptosis of cancer cells. Copyright © 2018. Published by Elsevier B.V.

基金：
Chinese Postdoctoral Science Foundation (No. 2017M612642), the Natural Science Foundation of Shandong Province (No. ZR2016HB20) and the National Natural Science Foundation of China (No. 81673627).
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 2 区 生物
小类 | 2 区 应用化学 2 区 高分子科学 3 区 生化与分子生物学
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 应用化学 2 区 高分子科学
JCR分区：
出版当年[2017]版：
Q1 POLYMER SCIENCE Q1 CHEMISTRY, APPLIED Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CHEMISTRY, APPLIED Q1 POLYMER SCIENCE

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [a]Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [d]School of Chinese Medicine, Shandong College of Traditional Chinese Medicine, Yantai 264199, Shangdong, PR China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Wu Jun,Li Hailun,Wang Xinyue,et al.Effect of polysaccharide from Undaria pinnatifida on proliferation, migration and apoptosis of breast cancer cell MCF7.[J].INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2019,121:734-742.doi:10.1016/j.ijbiomac.2018.10.086.
APA：
Wu Jun,Li Hailun,Wang Xinyue,Zhang Xiaolei,Liu Weiping...&Han Yun.(2019).Effect of polysaccharide from Undaria pinnatifida on proliferation, migration and apoptosis of breast cancer cell MCF7..INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,121,
MLA：
Wu Jun,et al."Effect of polysaccharide from Undaria pinnatifida on proliferation, migration and apoptosis of breast cancer cell MCF7.".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 121.(2019):734-742

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