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Associations of Serum testosterone and sex hormone-binding globulin with incident Arrhythmias in men from UK Biobank

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资源类型：
Pubmed体系：
作者：
Xu Bingyan[1] * ; Mo Wei[2] * ; Tan Xiangliang[3] * ; Zhang Peizhen[1] ; Huang Junlin[1] ; Huang Chensihan[1] ; Guo Dan[1] ; Wei Xueyun[1] ; Liu Yating[1] ; Lei Xuzhen[1] ; Dou Weijuan[1] ; Lin Jiayang[1] ; Liu Deying[1] ; Yang Linjie[1] ; Huang Yan[1] ; Zhang Huijie[1,4,5,*2] ; Liao Yunfei[6,*1] ;
机构： [1]Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China [2]Department of Endocrinology & Metabolism, Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou 510095, China [3]Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China [4]Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China [5]State Key Laboratory of Organ Failure Research, National Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China [6]Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
出处：
DOI： 10.1210/clinem/dgad526
ISSN：

关键词： testosterone sex hormone-binding globulin arrhythmias atrial fibrillation/flutter

摘要：
Sex hormones have been identified as cardiovascular risk factors, while the relationship between sex hormones and the risk of arrhythmias in men has not yet been well studied in the prospective cohort study.To analyze associations of serum testosterone, sex hormone-binding globulin (SHBG) concentrations and calculated free testosterone (cFT) with arrhythmias in men.Sex hormones were measured at baseline from UK Biobank. Main outcomes were incidence of atrial fibrillation/flutter (AF), ventricular arrhythmia (VA), bradyarrhythmia (BA).Of 173 498 men (aged 37 to 73 years, followed for 11 years), 11 368 had incident AF, 1 646 had incident VA, and 4 788 had incident BA. Compared with the third quartiles, the lowest category of serum testosterone was associated with increased risks of AF (HR 1.06, 95% CI 1.00-1.12) and BA (HR 1.11, 95% CI 1.02-1.20) after multivariable adjustment, but no VA. Likewise, similar associations were found between cFT values and AF and BA events. Furthermore, higher levels of cFT were associated with increased risks of AF (HR 1.07, 95% CI 1.02-1.13) and VA (HR 1.18, 95% CI 1.01-1.37). Higher SHBG concentrations were associated with increased risks of AF (HR 1.44, 95% CI 1.34-1.54), VA (HR 1.27, 95% CI 1.07-1.52), and BA (HR 1.17, 95% CI 1.05-1.29).Lower levels of testosterone and cFT were associated with increased risk of AF and BA. Higher cFT levels were associated with increased risk of AF and VA. Higher SHBG levels were associated with increased risk of AF, VA, and BA.© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

基金：
The National Key Research and Development Program of China (No. 2018YFA0800404); National Natural Science Foundation of China (No. 81970736); Key-Area Clinical Research Program of Southern Medical University (Nos. LC2019ZD010 and 2019CR022); The Joint Funds of the National Natural Science Foundation of China (U22A20288); National Natural Science Foundation of China (grant number: 82070830), and Key research and development project of Hubei Province (2022BCA036).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 内分泌学与代谢
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 内分泌学与代谢
第一作者：
第一作者机构： [1]Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China [4]Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China [5]State Key Laboratory of Organ Failure Research, National Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China [6]Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [*1]Department of Endocrinology, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, 1277 Jiefang Avenue, Jianghan District, Wuhan 430022, China [*2]Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Ave, Guangdong 510515, China.
推荐引用方式(GB/T 7714)：
Xu Bingyan,Mo Wei,Tan Xiangliang,et al.Associations of Serum testosterone and sex hormone-binding globulin with incident Arrhythmias in men from UK Biobank[J].The Journal of clinical endocrinology and metabolism.2023,doi:10.1210/clinem/dgad526.
APA：
Xu Bingyan,Mo Wei,Tan Xiangliang,Zhang Peizhen,Huang Junlin...&Liao Yunfei.(2023).Associations of Serum testosterone and sex hormone-binding globulin with incident Arrhythmias in men from UK Biobank.The Journal of clinical endocrinology and metabolism,,
MLA：
Xu Bingyan,et al."Associations of Serum testosterone and sex hormone-binding globulin with incident Arrhythmias in men from UK Biobank".The Journal of clinical endocrinology and metabolism .(2023)

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