机构：[1]Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, China[2]School of Clinical Medicine, Henan University, Kaifeng, China[3]The Second Affiliated Hospital (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou University of Chinese Medicine, Guangzhou, China广东省中医院[4]Nanshan School, Guangzhou Medical University, Guangzhou, China[5]First Clinical School, Guangzhou Medical University, Guangzhou, China[6]The First People’s Hospital of Zhaoqing, Zhaoqing, China[7]Southern Medical University, Guangzhou, China
Using Mendelian Randomization (MR) and large-scale Genome-Wide Association Study (GWAS) data, this study aimed to investigate the potential causative relationship between testosterone and sex hormone-binding globulin (SHBG) levels and the onset of several cancers, including pathway enrichment analyses of single nucleotide polymorphisms (SNPs) associated with cancer allowed for a comprehensive bioinformatics approach, which offered a deeper biological understanding of these relationships. The results indicated that increased testosterone levels in women were associated with a higher risk of breast and cervical cancers but a lower risk of ovarian cancer. Conversely, increased testosterone was linked to lower stomach cancer risk for men, whereas high SHBG levels were related to decreased risks of breast and prostate cancers. The corresponding genes of the identified SNPs, as revealed by pathway enrichment analysis, were involved in significant metabolic and proliferative pathways. These findings emphasize the need for further research into the biological mechanisms behind these associations, paving the way for potential targeted interventions in preventing and treating these cancers.
基金：
We acknowledge the First Affiliated Hospital of Guangzhou Medical University and State Key Laboratory of Respiratory Disease amp; National Clinical Research Center for Respiratory Disease for providing access to necessary resources for conducting this stu; First Affiliated Hospital of Guangzhou Medical University; State Key Laboratory of Respiratory Disease amp; National Clinical Research Center for Respiratory Disease
第一作者机构：[1]Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, China[6]The First People’s Hospital of Zhaoqing, Zhaoqing, China[7]Southern Medical University, Guangzhou, China[*1]Department of Thoracic Surgery, the First Affiliated Hospital of Guangzhou Medical University ,China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, China
推荐引用方式(GB/T 7714)：
Liu Xiwen,Lin Lixuan,Cai Qi,et al.Do testosterone and sex hormone-binding globulin affect cancer risk? A Mendelian randomization and bioinformatics study[J].AGING MALE.2023,26(1):doi:10.1080/13685538.2023.2261524.
APA：
Liu, Xiwen,Lin, Lixuan,Cai, Qi,Li, Caichen,Xu, Haoxiang...&He, Jianxing.(2023).Do testosterone and sex hormone-binding globulin affect cancer risk? A Mendelian randomization and bioinformatics study.AGING MALE,26,(1)
MLA：
Liu, Xiwen,et al."Do testosterone and sex hormone-binding globulin affect cancer risk? A Mendelian randomization and bioinformatics study".AGING MALE 26..1(2023)
