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Analysis of proteome and post-translational modifications of 2-hydroxyisobutyrylation reveals the glycolysis pathway in oral adenoid cystic carcinoma

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收录情况： ◇ SCIE

作者：
Chen Sining[1,2] * ; Li Dandan[1,3] * ; Zeng Zhipeng[1] ; Zhang Wei[1] ; Xie Hongliang[4] ; Tang Jianming[4] ; Liao Shengyou[1] ; Cai Wanxia[1] ; Liu Fanna[2] ; Tang Donge[1] ; Dai Yong[1,5,6,7] ;
机构： [1]Clinical Medical Research Center, The Second Clinical Medical College of Jinan University (Shenzhen People’s Hospital), Jinan University, Shenzhen 518020, Guangdong, China [2]Nephrology Department, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou 510632, China [3]Experimental Center, Shenzhen Pingle Orthopedic Hospital (Shenzhen Pingshan Traditional Chinese Medicine Hospital), Shenzhen, Guangdong 518118, China [4]Department of Oral and Maxillofacial Surgery, Stomatological Medical Center, The Second Clinical Medical College of Jinan University (Shenzhen People’s Hospital), Shenzhen 518020, Guangdong, China [5]Comprehensive health Industry Research Center, Taizhou Research Institute, Southern University of Science and Technology, Taizhou 318000, China [6]Department of Organ Transplantation, No.924 Hospital of PLA Joint Logistic Support Force, Medical quality specialty of the Joint Logistic Support Force, Guilin 541002, China [7]The first affiliated hospital, School of Medicine, Anhui University of Science and Technology, Huainan, Anhui 232001, China
出处：
DOI： 10.1186/s12957-023-03155-x
ISSN：

关键词： Glycolysis pathway Oral adenoid cystic carcinoma Lysine 2-hydroxyisobutyrylation Proteomics Therapeutics

摘要：
Oral adenoid cystic carcinoma (OACC) has high rates of both local-regional recurrence and distant metastasis. The objective of this study is to investigate the impact of Khib on OACC and its potential as a targeted therapeutic intervention. EXPERIMENTAL DESIGN: We investigated the DEPs (differentially expressed proteins) and DHMPs between OACC-T and OACC-N using LC-MS/MS-based quantitative proteomics and using several bioinformatics methods, including GO enrichment analysis, KEGG pathway analysis, subcellular localization prediction, MEA (motif enrichment analysis), and PPI (protein-protein interaction networks) to illustrate how Khib modification interfere with OACC evolution.Compared OACC-tumor samples (OACC-T) with the adjacent normal samples (OACC-N), there were 3243 of the DEPs and 2011 Khib sites were identified on 764 proteins (DHMPs). DEPs and DHMPs were strongly associated to glycolysis pathway. GAPDH of K254, ENO of K228, and PGK1 of K323 were modified by Khib in OACC-T. Khib may increase the catalytic efficiency to promote glycolysis pathway and favor OACC progression.Khib may play a significant role in the mechanism of OACC progression by influencing the enzyme activity of the glycolysis pathway. These findings may provide new therapeutic options of OACC.© 2023. BioMed Central Ltd., part of Springer Nature.

基金：
This work was supported by the Postdoctoral Science Foundation of China (No. 2020M683199), General Project of Basic Research of Shenzhen Natural Science Foundation (No. JCYJ20220530152406015).
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 3 区 外科 4 区 肿瘤学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 肿瘤学 3 区 外科
JCR分区：
出版当年[2021]版：
Q2 SURGERY Q3 ONCOLOGY
最新[2023]版：
Q1 SURGERY Q3 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Clinical Medical Research Center, The Second Clinical Medical College of Jinan University (Shenzhen People’s Hospital), Jinan University, Shenzhen 518020, Guangdong, China [2]Nephrology Department, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou 510632, China
共同第一作者：
通讯作者：
通讯机构： [1]Clinical Medical Research Center, The Second Clinical Medical College of Jinan University (Shenzhen People’s Hospital), Jinan University, Shenzhen 518020, Guangdong, China [5]Comprehensive health Industry Research Center, Taizhou Research Institute, Southern University of Science and Technology, Taizhou 318000, China [6]Department of Organ Transplantation, No.924 Hospital of PLA Joint Logistic Support Force, Medical quality specialty of the Joint Logistic Support Force, Guilin 541002, China [7]The first affiliated hospital, School of Medicine, Anhui University of Science and Technology, Huainan, Anhui 232001, China
推荐引用方式(GB/T 7714)：
Chen Sining,Li Dandan,Zeng Zhipeng,et al.Analysis of proteome and post-translational modifications of 2-hydroxyisobutyrylation reveals the glycolysis pathway in oral adenoid cystic carcinoma[J].WORLD JOURNAL OF SURGICAL ONCOLOGY.2023,21(1):doi:10.1186/s12957-023-03155-x.
APA：
Chen Sining,Li Dandan,Zeng Zhipeng,Zhang Wei,Xie Hongliang...&Dai Yong.(2023).Analysis of proteome and post-translational modifications of 2-hydroxyisobutyrylation reveals the glycolysis pathway in oral adenoid cystic carcinoma.WORLD JOURNAL OF SURGICAL ONCOLOGY,21,(1)
MLA：
Chen Sining,et al."Analysis of proteome and post-translational modifications of 2-hydroxyisobutyrylation reveals the glycolysis pathway in oral adenoid cystic carcinoma".WORLD JOURNAL OF SURGICAL ONCOLOGY 21..1(2023)

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