机构：[1]Department of Laboratory Medicine, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, China[2]The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China[3]Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China[4]Guangdong Provincial Center for Disease Control and Prevention, Guangdong Workstation for Emerging Infectious Disease Controland Prevention, Guangzhou, China[5]Emergency Department, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, China[6]Research and Development Centers, and 7Department of Medical Affairs, Autobio Diagnostics Co.Ltd.,Zhengzhou, China[7]Guangdong Center for Disease Control and Prevention, Guangdong Provincial Institute of Public Health, Guangzhou, China[8]Department of Pulmonary and Critical Care Medicine, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, China
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine has been used worldwide on a large scale because of its potent ability to contain the coronavirus disease 2019 (COVID-19) pandemic, and the antibody response induced by the vaccine needs to be elucidated. Thus, we conducted a prospective trial in healthy subjects to observe the antibody response after three doses of inactivated vaccines. Our results showed that neutralizing antibody (NAb) levels were significantly higher after the booster vaccination compared to the second, a 4.9-fold increase, with the peak occurring at 28 days. The NAb level could be maintained for a longer period after the third vaccination, with higher levels still observed after 3 months. We did not observe significantly higher levels of SARS-CoV-2 spike-specific immunoglobulin G (S-IgG) and immunoglobulin M (IgM) after the third vaccination compared with the second vaccination; this was especially true for SARS-CoV-2 spike-specific immunoglobulin M (S-IgM), which was barely expressed. Notably, those who did not undergo NAb seroconversion after two doses of the vaccine produced high and long-lasting NAb after the third vaccination, confirming that they were not completely unresponsive to the vaccine. The NAb titer in younger subjects (aged 20-40 years) rose 3.4-fold compared with older subjects (aged 40-60 years) after the second vaccination, but the difference was narrowed after the third vaccination (2.8-fold increase). In addition, the levels of antibodies in older men were 3.4-fold lower than those in the older women after the third vaccination. Overall, this study elucidates the dynamic change in antibodies after three doses of vaccination, which provides a reference for the improvement of vaccination strategies.
基金：
This work was supported by the Science and Technology
Innovation Project of Foshan Municipality (2020001000431);
the National Key Research and Development Program
(2021YFC0863300); and the Emergency Key Program of
Guangzhou Laboratory (EKPG21–27).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|4 区医学
小类|4 区免疫学4 区病毒学
最新[2025]版：
大类|4 区医学
小类|4 区免疫学4 区病毒学
第一作者：
第一作者机构：[1]Department of Laboratory Medicine, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Laboratory Medicine, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, China[*1]Department of Laboratory Medicine Shunde Hospital of Guangzhou University of Chinese Medicine No. 12 Jinsha Avenue Shunde District Foshan 528300 Guangdong Province China[*2]Department of Pulmonary and Critical Care Medicine Shunde Hospital of Guangzhou University of Chinese Medicine Foshan 528300 Guangdong Province China
推荐引用方式(GB/T 7714)：
Ji Ruili,Zhang Jiaqi,Liang Dan,et al.Potent Antibody Response Elicited by a Third Booster Dose of Inactivated COVID-19 Vaccine in Healthy Subjects[J].Viral immunology.2023,doi:10.1089/vim.2023.0072.
APA：
Ji Ruili,Zhang Jiaqi,Liang Dan,Quan Hongbing,Wu Yue...&Xu Jianhua.(2023).Potent Antibody Response Elicited by a Third Booster Dose of Inactivated COVID-19 Vaccine in Healthy Subjects.Viral immunology,,
MLA：
Ji Ruili,et al."Potent Antibody Response Elicited by a Third Booster Dose of Inactivated COVID-19 Vaccine in Healthy Subjects".Viral immunology .(2023)
