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Integrating network pharmacology and experimental verification strategies to reveal the active ingredients and molecular mechanism of Tenghuang Jiangu Capsule against osteoporosis

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Li Miao[1,3] * ; Tang Hongyu[1,2] * ; Hu Yuanhao[1] ; Li Songtao[1,3] ; Kang Pan[1,3] ; Chen Baihao[1,3] ; Li Shaocong[1,3] ; Zhang Meng[4] ; Wang Haibin[1,2,3,*1] ; Huo Shaochuan[5] ;
机构： [1]Guangzhou University of Chinese Medicine, Guangzhou, 510405, China [2]Department of Joint Orthopaedic, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China [3]Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China [4]Department of Orthopedics, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University, Zhengzhou, 450003, China [5]Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, No.6001, North Ring Road, Futian District, Shenzhen City, Guangdong Province, 518048, China
出处：
DOI： 10.1016/j.heliyon.2023.e19812

关键词： Teng Huang Jian Gu capsule (THJGC) Osteoporosis Network pharmacology Bone formation Experimental validation

摘要：
Tenghuang Jiangu Capsule (THJGC) is a Chinese herbal formula used for the treatment of osteoporosis and osteoarthritis in China, but its mechanism for treating osteoporosis is not clear. The aim of this study was to investigate the therapeutic effect of THJGC on osteoporosis and its intrinsic mechanism through network pharmacology and experimental validation. Drugs and potential targets were obtained from several reliable databases through network pharmacology, and these targets were integrated and analyzed using bioinformatics and molecular docking strategies. Quercetin, lignans and kaempferol were identified as key components, and the key targets included Akt1, MAPKs, and CASP3. Subsequently, UPLC-MS/MS analysis confirmed the presence of components in THJGC for the treatment of osteoporosis. In addition, using ex vivo and in vivo models, it was confirmed that THJGC inhibited H2O2-induced ROS generation and apoptosis, and reduced OVX-induced bone loss in a mouse model of osteoporosis. Our data suggest that THJGC has antioxidant, bone formation-promoting, bone resorption-inhibiting, and MC3T3-E1 apoptosis-reducing effects, and thus has anti-osteoporotic properties. In conclusion, it may be a promising pharmacologic adjuvant treatment for osteoporosis.© 2023 The Authors.

基金：
This study was supported by the National Natural Science Foundation of China (No: 82074462, 82004395); Shenzhen Futian District Health and Public Welfare Scientific Research Project (FTWS2020058); Henan Scientific and Technological Research Project (No: 222102310124); the Joint Construction Project of Henan Provincial Health Committee and Ministry of Health (No: LHGJ20210035).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 4 区 综合性期刊
小类 | 4 区 综合性期刊
最新[2025]版：
大类 | 4 区 综合性期刊
小类 | 4 区 综合性期刊
JCR分区：
出版当年[2021]版：
Q2 MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Guangzhou University of Chinese Medicine, Guangzhou, 510405, China [3]Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China
共同第一作者：
通讯作者：
通讯机构： [1]Guangzhou University of Chinese Medicine, Guangzhou, 510405, China [2]Department of Joint Orthopaedic, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China [3]Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China [*1]Department of Joint Orthopaedic, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
推荐引用方式(GB/T 7714)：
Li Miao,Tang Hongyu,Hu Yuanhao,et al.Integrating network pharmacology and experimental verification strategies to reveal the active ingredients and molecular mechanism of Tenghuang Jiangu Capsule against osteoporosis[J].HELIYON.2023,9(9):e19812.doi:10.1016/j.heliyon.2023.e19812.
APA：
Li Miao,Tang Hongyu,Hu Yuanhao,Li Songtao,Kang Pan...&Huo Shaochuan.(2023).Integrating network pharmacology and experimental verification strategies to reveal the active ingredients and molecular mechanism of Tenghuang Jiangu Capsule against osteoporosis.HELIYON,9,(9)
MLA：
Li Miao,et al."Integrating network pharmacology and experimental verification strategies to reveal the active ingredients and molecular mechanism of Tenghuang Jiangu Capsule against osteoporosis".HELIYON 9..9(2023):e19812

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