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Network pharmacology analysis and experimental validation of Xiao-Qing-Long-Tang's therapeutic effects against neutrophilic asthma

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机构： [1]Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China [2]The Emergency Department, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China [3]The Physical Examination Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China [4]Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China [5]Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China [6]Department of Emergency Medicine, The Second Xiangya Hospital of Central South University, Emergency and Difficult Diseases Institute of Central South University, Changsha, Hunan, P. R. China [7]Department of Emergency Medicine, The Guilin Hospital of The Second Xiangya Hospital of Central South University, Guilin, Guangxi, China [8]Department of Chinese Medicine, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China

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关键词： Dendritic cells Network Pharmacology Neutrophilic asthma Th2/17 Xiao-Qing-Long-Tang

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Xiao-Qing-Long-Tang (XQLT), a classical Chinese herbal medicine formula, has been extensively used for allergic asthma treatment. However, there is limited research on its anti-inflammatory effects and mechanisms specifically in neutrophilic asthma (NA).This study aims to investigate the potential therapeutic effects of XQLT against NA using a combination of network pharmacology and experimental validation.By utilizing traditional Chinese medicine and disease databases, we constructed an XQLT-asthma network to identify potential targets of XQLT for NA. In the experimental phase, we utilized an ovalbumin (OVA)/lipopolysaccharide (LPS)-induced model for neutrophilic asthma and examined the therapeutic effects of XQLT.Our research identified 174 bioactive components within XQLT and obtained 140 target genes of XQLT against asthma. Functional enrichment analysis revealed that these target genes were primarily associated with inflammation and cytokines. In the experimental validation, mice induced with OVA-LPS showcased eosinophilic and neutrophilic cell infiltration in peri-bronchial areas, elevated levels of IL-4 and IL-17 in both serum and lung, increased percentages of Th2 and Th17 cells in the spleen, as well as elevated levels of CD11b+ and CD103+ dendritic cells (DCs) within the lung. Treatment with XQLT effectively reduced IL-4 and IL-17 levels, decreased the percentages of Th2, Th17, CD11b+, and CD103+ DCs, and improved inflammatory cell infiltrations in lung tissues. These findings serve as a foundation for the potential clinical application of XQLT in neutrophilic asthma.Copyright © 2024. Published by Elsevier B.V.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 2 区分析化学 3 区药学

最新[2025]版：

大类 | 3 区医学

小类 | 2 区分析化学 3 区药学

第一作者：

第一作者机构： [1]Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China

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通讯机构： [6]Department of Emergency Medicine, The Second Xiangya Hospital of Central South University, Emergency and Difficult Diseases Institute of Central South University, Changsha, Hunan, P. R. China [7]Department of Emergency Medicine, The Guilin Hospital of The Second Xiangya Hospital of Central South University, Guilin, Guangxi, China

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