Identifying NFKB1, STAT3, and CDKN1A as Baicalein's Potential Hub Targets in Parkinson's Disease-related α-synuclein-mediated Pathways by Integrated Bioinformatics Strategies
Background: The overexpression, accumulation, and cell-to-cell transmission of alpha-synuclein leads to the deterioration of Parkinson's disease (PD). Previous studies suggest that Baicalein (BAI) can bind to alpha-synuclein and inhibit alpha-synuclein aggregation and secretion. However, it is still unclear whether BAI can intervene with the pathogenic molecules in alpha-synuclein-mediated PD pathways beyond directly targeting alpha-synuclein per se.Methods: This study aimed to systematically investigate BAI's potential targets in PD-related A53T mutant alpha-synuclein-mediated pathways by integrating data mining, network pharmacological analysis, and molecular docking simulation techniques.Results: The results suggest that BAI may target genes that are dysregulated in synaptic transmission, vesicle trafficking, gene transcription, protein binding, extracellular matrix formation, and kinase activity in alpha-synuclein-mediated pathways. NFKB1, STAT3, and CDKN1A are BAI's potential hub targets in these pathways.Conclusion: Our findings highlight BAI's potentiality to modulate alpha-synuclein-mediated pathways beyond directly targeting alpha-synuclein per se.
基金：
National Natural Science Foundation of China [81903958, 81870856, 81870992, 82071416]; China Postdoctoral Science Foundation [2019M662873]; Postdoctoral Funds for Scientific Research Initiation from Guangzhou Municipal Human Resources and Social Security Bureau [02018055]; Postdoctoral International Exchange Program from Guangzhou Municipal Human Resources and Social Security Bureau [Q04001]; National Natural Science Foundation Cultivation Project from The First Affiliated Hospital of Guangzhou Medical University [81903958]; Central Government Guiding Local Science and Technology Development Projects [ZYYD2022C17]; Key Project of Guangzhou Health Commission [2019-ZD-09]; Municipal University (Faculty) Joint Funding Project [202102010010]; Guangzhou Key RD Plan [SL2022B03J00067]; Guangzhou medical key discipline project (2021-2023)
第一作者机构：[1]Guangzhou Med Univ, Affiliated Hosp 1, Dept Neurol, Guangzhou, Peoples R China
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推荐引用方式(GB/T 7714)：
Li Xingjian,Deng Qiyin,Kuang Yaoyun,et al.Identifying NFKB1, STAT3, and CDKN1A as Baicalein's Potential Hub Targets in Parkinson's Disease-related α-synuclein-mediated Pathways by Integrated Bioinformatics Strategies[J].CURRENT PHARMACEUTICAL DESIGN.2023,29(30):2426-2437.doi:10.2174/0113816128259065231011114116.
APA：
Li, Xingjian,Deng, Qiyin,Kuang, Yaoyun,Mao, Hengxu,Yao, Meiling...&Xu, Pingyi.(2023).Identifying NFKB1, STAT3, and CDKN1A as Baicalein's Potential Hub Targets in Parkinson's Disease-related α-synuclein-mediated Pathways by Integrated Bioinformatics Strategies.CURRENT PHARMACEUTICAL DESIGN,29,(30)
MLA：
Li, Xingjian,et al."Identifying NFKB1, STAT3, and CDKN1A as Baicalein's Potential Hub Targets in Parkinson's Disease-related α-synuclein-mediated Pathways by Integrated Bioinformatics Strategies".CURRENT PHARMACEUTICAL DESIGN 29..30(2023):2426-2437
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