机构：[1]Hunan Univ Chinese Med, Hosp 1, Dept Rheumatol, Changsha, Hunan, Peoples R China[2]Hunan Univ Chinese Med, Inst Innovat & Appl Res Chinese Med, Changsha, Hunan, Peoples R China[3]Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha, Hunan, Peoples R China[4]Dalian Med Univ, Inst Coll Integrat Med, Dalian, Liaoning, Peoples R China[5]Cent South Univ, Xiangya Hosp 2, Dept Neurosurg, Changsha, Hunan, Peoples R China[6]Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Dampness Syndrome Chinese Med, Guangzhou, Guangdong, Peoples R China广东省中医院
Angiogenesis plays a key role in the pathological process of inflammation and invasion of the synovium, and primarily drives the progression of rheumatoid arthritis (RA). Recent studies have demonstrated that the Notch signaling may represent a new therapeutic target of RA. Although the Notch signaling has been implicated in the M1 polarization of macrophages and the differentiation of lymphocytes, little is known about its role in angiogenesis in RA. In this review, we discourse the unique roles of stromal cells and adipokines in the angiogenic progression of RA, and investigate how epigenetic regulation of the Notch signaling influences angiogenesis in RA. We also discuss the interaction of the Notch-HIF signaling in RA's angiogenesis and the potential strategies targeting the Notch signaling to improve the treatment outcomes of RA. Taken together, we further suggest new insights into future research regarding the challenges in the therapeutic strategies of RA.
基金：
National Natural Science Foundation of China General Program (82274506), Science and Technology [82274506]; National Natural Science Foundation of China General Program [2020SK1020, 2021RC4035]; Science and Technology Innovation Program of Hunan Province [22JBZ003]; Open-Competing Disciple Construction Project of Hunan University of Chinese Medicine [XJT[2020]58]; Hunan Furong Distinguished Scholar Program [XRSH[2019]192, [2021]4-21YS001]; Hunan 121 Training Project for Innovative Talents [[2022]57]; World First-class Discipline Incubation Project of HNUCM (XJF)
第一作者机构：[1]Hunan Univ Chinese Med, Hosp 1, Dept Rheumatol, Changsha, Hunan, Peoples R China[2]Hunan Univ Chinese Med, Inst Innovat & Appl Res Chinese Med, Changsha, Hunan, Peoples R China[3]Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha, Hunan, Peoples R China
通讯作者：
通讯机构：[1]Hunan Univ Chinese Med, Hosp 1, Dept Rheumatol, Changsha, Hunan, Peoples R China[2]Hunan Univ Chinese Med, Inst Innovat & Appl Res Chinese Med, Changsha, Hunan, Peoples R China
推荐引用方式(GB/T 7714)：
Zhao Fang,He Yini,Zhao Zhihao,et al.The Notch signaling-regulated angiogenesis in rheumatoid arthritis: pathogenic mechanisms and therapeutic potentials[J].FRONTIERS IN IMMUNOLOGY.2023,14:doi:10.3389/fimmu.2023.1272133.
APA：
Zhao, Fang,He, Yini,Zhao, Zhihao,He, Jiarong,Huang, Hong...&Cai, Xiong.(2023).The Notch signaling-regulated angiogenesis in rheumatoid arthritis: pathogenic mechanisms and therapeutic potentials.FRONTIERS IN IMMUNOLOGY,14,
MLA：
Zhao, Fang,et al."The Notch signaling-regulated angiogenesis in rheumatoid arthritis: pathogenic mechanisms and therapeutic potentials".FRONTIERS IN IMMUNOLOGY 14.(2023)
医学