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Notch signaling: Its essential roles in bone and craniofacial development (Open Access)

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收录情况： ◇ SCIE ◇ 卓越：高起点新刊

作者：
Mikhail Pakvasa[a,b,c] * ; Pranav Haravu[b] ; Michael Boachie-Mensah[a,b] ; Alonzo Jones[b] ; Elam Coalson[a,b] ; Junyi Liao[a,d] ; Zongyue Zeng[a,e] ; Di Wu[a] ; Kevin Qin[a] ; Xiaoxing Wu[a,d] ; Huaxiu Luo[a,f] ; Jing Zhang[a,d] ; Meng Zhang[a,g] ; Fang He[a,d] ; Yukun Mao[a,h] ; Yongtao Zhang[a,i] ; Changchun Niu[a,j] ; Meng Wu[a,k] ; Xia Zhao[a,i] ; Hao Wang[a,e] ; Linjuan Huang[a,d] ; Deyao Shi[a,l] ; Qing Liu[a,m] ; Na Ni[a,e] ; Kai Fu[a,h] ; Michael J. Lee[a] ; Jennifer Moriatis Wolf[a] ; Aravinda thiviraham[a] ; Sherwin S. Ho[a] ; Tong-Chuan He[a] ; Kelly Hynes[a] ; Jason Strelzow[a] ; Mostafa El Dafrawy[a] ; Russell R. Reid[a,c] ;
机构： [a]Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine,The University of Chicago Medical Center, Chicago, IL, 60637, USA [b]Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA [c]Section of Plastic and Reconstructive Surgery, Department of Surgery, The University of ChicagoMedical Center, Chicago, IL, 60637, USA [d]Departments of Orthopaedic Surgery, Gastrointestinal Surgery, Obstetrics and Gynecology, andNephrology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China [e]Ministry of Education Key Laboratory of Diagnostic Medicine, and School of Laboratory and DiagnosticMedicine, Chongqing Medical University, Chongqing, 400016, China [f]Department of Burn and Plastic Surgery, West China Hospital of Sichuan University, Chengdu 610041,China [g]Department of Orthopaedic Surgery, The First Affiliated Hospital, Guangzhou University of ChineseMedicine, Guangzhou 510405, China [h]Departments of Orthopaedic Surgery and Neurosurgery, The Affiliated Zhongnan Hospital of WuhanUniversity, Wuhan 430072, China [i]Department of Orthopaedic Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266061,China [j]Department of Laboratory Diagnostic Medicine, Chongqing General Hospital, Chongqing 400021,China [k]Institute of Bone and Joint Research, and the Department of Orthopaedic Surgery, The SecondHospitals of Lanzhou University, Lanzhou, 730030, China [l]Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Scienceand Technology, Wuhan 430022, China [m]Department of Spine Surgery, Second Xiangya Hospital, Central South University, Changsha 410011,China
出处：
DOI： 10.1016/j.gendis.2020.04.006
ISSN：

关键词： Alagille syndrome Bone Craniofacial development Craniosynostosis Notch Oncogenesis Osteogenesis Spondylocostal dysosotosis

摘要：
Notch is a cell–cell signaling pathway that is involved in a host of activities including development, oncogenesis, skeletal homeostasis, and much more. More specifically, recent research has demonstrated the importance of Notch signaling in osteogenic differentiation, bone healing, and in the development of the skeleton. The craniofacial skeleton is complex and understanding its development has remained an important focus in biology. In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton, skull, and face develop. We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system, and what importance it may play in the future. © 2020 Chongqing Medical University

基金：
The reported work was supported in part by research grants from the National Institutes of Health ( CA226303 to TCH), the U.S. Department of Defense ( OR130096 to JMW) and the Scoliosis Research Society (TCH and MJL). MP was supported in part by the Pritzker-Northshore Fellowship at The University of Chicago . WW was supported by the Medical Scientist Training Program of the National Institutes of Health ( T32 GM007281 ). This project was also supported in part by The University of Chicago Cancer Center Support Grant ( P30CA014599 ) and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1 TR000430 . TCH was supported by the Mabel Green Myers Research Endowment Fund and The University of Chicago Orthopaedics Alumni Fund . Funding sources were not involved in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
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中科院(CAS)分区：
出版当年[2020]版：
大类 | 2 区 医学
小类 | 2 区 生化与分子生物学 2 区 遗传学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 生化与分子生物学 2 区 遗传学
JCR分区：
出版当年[2019]版：
Q1 GENETICS & HEREDITY Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 GENETICS & HEREDITY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [a]Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine,The University of Chicago Medical Center, Chicago, IL, 60637, USA [b]Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA [c]Section of Plastic and Reconstructive Surgery, Department of Surgery, The University of ChicagoMedical Center, Chicago, IL, 60637, USA
通讯作者：
通讯机构： [a]Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine,The University of Chicago Medical Center, Chicago, IL, 60637, USA [c]Section of Plastic and Reconstructive Surgery, Department of Surgery, The University of ChicagoMedical Center, Chicago, IL, 60637, USA
推荐引用方式(GB/T 7714)：
Mikhail Pakvasa,Pranav Haravu,Michael Boachie-Mensah,et al.Notch signaling: Its essential roles in bone and craniofacial development (Open Access)[J].GENES & DISEASES.2021,8(1):8-24.doi:10.1016/j.gendis.2020.04.006.
APA：
Mikhail Pakvasa,Pranav Haravu,Michael Boachie-Mensah,Alonzo Jones,Elam Coalson...&Russell R. Reid.(2021).Notch signaling: Its essential roles in bone and craniofacial development (Open Access).GENES & DISEASES,8,(1)
MLA：
Mikhail Pakvasa,et al."Notch signaling: Its essential roles in bone and craniofacial development (Open Access)".GENES & DISEASES 8..1(2021):8-24

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