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MYL9 promotes squamous cervical cancer migration and invasion by enhancing aerobic glycolysis

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收录情况： ◇ SCIE

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机构： [1]Jinan Univ, Clin Coll 1, Guangzhou, Guangdong, Peoples R China [2]Guangdong Women & Children Hosp, Dept Gynecol, Guangzhou, Peoples R China [3]Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou, Guangdong, Peoples R China [4]Southern Med Univ, Integrated Hosp Tradit Chinese Med, Dept Gynecol, Guangzhou, Peoples R China [5]Guangdong Women & Children Hosp, Dept Gynecol, 521 Xing Nan Da Dao, Guangzhou 511442, Guangdong, Peoples R China

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关键词： Myosin light chain 9 squamous cervical cancer aerobic glycolysis migration invasion Janus kinase 2 signal transducer activator of transcription

摘要：

Objective: This study explored the mechanism of squamous cervical cancer (SCC) progression.Methods: Reverse transcription-quantitative polymerase chain reaction and western blotting were used to evaluate the expression of myosin light chain 9 (MYL9) in SCC tissues and cell lines. Furthermore, Transwell and Boyden assays were used to assess the function of MYL9 in SCC progression. In addition, the levels of lactate and aerobic glycolysis were used to explore the detailed mechanism of MYL9 in SCC.Results: The mRNA and protein levels of MYL9 were elevated in SCC tissues, and MYL9 knockdown inhibited the migration and invasion of SCC cell lines. A mechanistic study demonstrated that MYL9 promotes SCC migration and invasion by enhancing aerobic glycolysis and increasing the activity of the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway.Conclusions: MYL9 was upregulated in SCC, and it enhanced JAK2/STAT3 pathway activity and promoted metastasis and glycolysis in SCC.

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出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区药学 4 区医学：研究与实验

最新[2025]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验 4 区药学

JCR分区：

出版当年[2021]版：

Q4 MEDICINE, RESEARCH & EXPERIMENTAL Q4 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q4 MEDICINE, RESEARCH & EXPERIMENTAL Q4 PHARMACOLOGY & PHARMACY

影响因子： 1.4 最新[2023版] 1.8 最新五年平均 1.573 出版当年[2021版] 1.803 出版当年五年平均 1.671 出版前一年[2020版] 1.6 出版后一年[2022版]

第一作者：

第一作者机构： [1]Jinan Univ, Clin Coll 1, Guangzhou, Guangdong, Peoples R China [2]Guangdong Women & Children Hosp, Dept Gynecol, Guangzhou, Peoples R China

通讯作者：

通讯机构： [1]Jinan Univ, Clin Coll 1, Guangzhou, Guangdong, Peoples R China [2]Guangdong Women & Children Hosp, Dept Gynecol, Guangzhou, Peoples R China [5]Guangdong Women & Children Hosp, Dept Gynecol, 521 Xing Nan Da Dao, Guangzhou 511442, Guangdong, Peoples R China

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