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Psoralea corylifolia formula extract-loaded silk fibroin/polycaprolactone fibrous membrane for the treatment of colorectal cancer

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机构: [1]National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, Jiangsu, China [2]School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Department of Medical Oncology and Cancer Institute of Medicine, Shuguang Hospital, Shanghai 201203, China [3]Department of General Surgery (Colorectal Surgery) & Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases & Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, Guangdong, China [4]Department of Biomedical Engineering, 4 Colby Street, Tufts University, Medford, MA 02155, USA [5]The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital.Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation.School of Biomedical Engineering, Guangzhou Medical University, Guangzhou 511436, Guangdong, China
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关键词: Psoralea corylifolia formula extract Colorectal cancer Silk fibroin Polycaprolactone Emulsion electrospinning

摘要:
Intestinal obstructions caused by intestinal tumors pose life-threatening risks to patients. Adjuvant treatment using intestinal stents carrying drug loaded membranes has the advantages of timely relief of intestinal obstruction, as well as effective inhibition of tumor progression. The present work is to develop an intestinal stent loaded with a combination of traditional Chinese medicines capable of good biocompatibility, degradability, sustained drug release and anti-tumor properties. The drug combination extract was obtained from Psoralea corylifolia formula (PCF) and then was loaded into silk fibroin (SF)/polycaprolactone (PCL) fibrous membranes using emulsion electrospinning technology. Results showed that the membrane prepared by emulsion electrospinning technology has apparent core-shell structure, and the mechanical property and hydrophilicity of the membrane are gradually improved with the addition of PCF. Drug sustained release results demonstrated that there were no bursting phenomena, and showed a gradual sustained release up to 400 h. The antitumor efficacy was assessed in vitro using a human colorectal cancer cell line HCT-116 and an epithelial cell line NCM-460. Results showed that this drug-loaded membrane sustained antitumor cell growth performance, indicating its great potential for clinical treatment for intestinal cancer in the near future.Copyright © 2023 Elsevier B.V. All rights reserved.

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出版当年[2023]版:
大类 | 2 区 医学
小类 | 1 区 生物物理 2 区 物理化学 3 区 材料科学:生物材料
最新[2025]版:
大类 | 2 区 医学
小类 | 1 区 生物物理 3 区 材料科学:生物材料
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出版当年[2022]版:
Q1 BIOPHYSICS Q2 CHEMISTRY, PHYSICAL Q2 MATERIALS SCIENCE, BIOMATERIALS
最新[2023]版:
Q1 BIOPHYSICS Q2 CHEMISTRY, PHYSICAL Q2 MATERIALS SCIENCE, BIOMATERIALS

影响因子: 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

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第一作者机构: [1]National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, Jiangsu, China
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